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Note 9 - Stockholders' Equity - Exercise Price Range (Details)	12 Months Ended
	Dec. 31, 2018 $ / shares shares
Options Outstanding (in shares) | shares	15,264,606
Exercise Price Range 1 [Member]
Options Outstanding (in shares) | shares	2,635,453
Range of Exercise Prices, Lower Limit (in dollars per share)	$ 5.20
Range of Exercise Prices, Upper Limit (in dollars per share)	$ 9.05
Weighted- Average Remaining Contractual Life (Year)	3 years 10 days
Weighted- Average Exercise Price (in dollars per share)	$ 7.99
Options Exercisable (in shares) | shares	2,260,453
Weighted- Average Exercise Price of Options Exercisable (in dollars per share)	$ 8.12
Exercise Price Range 2 [Member]
Options Outstanding (in shares) | shares	2,531,622
Range of Exercise Prices, Lower Limit (in dollars per share)	$ 9.33
Range of Exercise Prices, Upper Limit (in dollars per share)	$ 14.20
Weighted- Average Remaining Contractual Life (Year)	6 years 105 days
Weighted- Average Exercise Price (in dollars per share)	$ 12.89
Options Exercisable (in shares) | shares	1,406,228
Weighted- Average Exercise Price of Options Exercisable (in dollars per share)	$ 12.66
Exercise Price Range 3 [Member]
Options Outstanding (in shares) | shares	4,195,066
Range of Exercise Prices, Lower Limit (in dollars per share)	$ 14.25
Range of Exercise Prices, Upper Limit (in dollars per share)	$ 17
Weighted- Average Remaining Contractual Life (Year)	7 years 284 days
Weighted- Average Exercise Price (in dollars per share)	$ 16.60
Options Exercisable (in shares) | shares	1,512,260
Weighted- Average Exercise Price of Options Exercisable (in dollars per share)	$ 16.54
Exercise Price Range 4 [Member]
Options Outstanding (in shares) | shares	845,157
Range of Exercise Prices, Lower Limit (in dollars per share)	$ 17.05
Range of Exercise Prices, Upper Limit (in dollars per share)	$ 23.90
Weighted- Average Remaining Contractual Life (Year)	7 years 204 days
Weighted- Average Exercise Price (in dollars per share)	$ 20.52
Options Exercisable (in shares) | shares	478,721
Weighted- Average Exercise Price of Options Exercisable (in dollars per share)	$ 20.64
Exercise Price Range 5 [Member]
Options Outstanding (in shares) | shares	2,860,911
Range of Exercise Prices, Lower Limit (in dollars per share)	$ 24.97
Range of Exercise Prices, Upper Limit (in dollars per share)	$ 24.97
Weighted- Average Remaining Contractual Life (Year)	8 years 343 days
Weighted- Average Exercise Price (in dollars per share)	$ 24.97
Options Exercisable (in shares) | shares
Weighted- Average Exercise Price of Options Exercisable (in dollars per share)
Exercise Price Range 6 [Member]
Options Outstanding (in shares) | shares	2,196,397
Range of Exercise Prices, Lower Limit (in dollars per share)	$ 25.06
Range of Exercise Prices, Upper Limit (in dollars per share)	$ 39.25
Weighted- Average Remaining Contractual Life (Year)	7 years 153 days
Weighted- Average Exercise Price (in dollars per share)	$ 30.85
Options Exercisable (in shares) | shares	865,431
Weighted- Average Exercise Price of Options Exercisable (in dollars per share)	$ 29.71
Exercise Price Range 7 [Member]
Options Outstanding (in shares) | shares	15,264,606
Range of Exercise Prices, Lower Limit (in dollars per share)	$ 5.20
Range of Exercise Prices, Upper Limit (in dollars per share)	$ 39.25
Weighted- Average Remaining Contractual Life (Year)	6 years 317 days
Weighted- Average Exercise Price (in dollars per share)	$ 18.33
Options Exercisable (in shares) | shares	6,523,093
Weighted- Average Exercise Price of Options Exercisable (in dollars per share)	$ 14.83

X

- Definition

The floor of a customized range of exercise prices for purposes of disclosing shares potentially issuable under outstanding stock option awards on all stock option plans and other required information pertaining to awards in the customized range.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (g)
-URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901

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- Definition

The number of shares reserved for issuance pertaining to the outstanding exercisable stock options as of the balance sheet date in the customized range of exercise prices for which the market and performance vesting condition has been satisfied.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
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-Topic 718
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-Section 50
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- Definition

The number of shares reserved for issuance pertaining to the outstanding stock options as of the balance sheet date for all option plans in the customized range of exercise prices.

+ References

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
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The ceiling of a customized range of exercise prices for purposes of disclosing shares potentially issuable under outstanding stock option awards on all stock option plans and other required information pertaining to awards in the customized range.

+ References

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- Definition

Weighted average exercise price as of the balance sheet date for those equity-based payment arrangements exercisable and outstanding.

+ References

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- Definition

The weighted average price as of the balance sheet date at which grantees could acquire the underlying shares with respect to all outstanding stock options which are in the customized range of exercise prices.

+ References

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- Definition

Weighted average remaining contractual term of outstanding stock options, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

+ References

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