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Note 10 - Income Taxes - Provisions (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Tax at statutory federal rate	$ (37,557)	$ (67,145)	$ (58,868)
State tax, net of federal benefit	(6,527)	(6,203)	2,013
Research and development credits	(4,775)	(5,962)	(4,206)
Stock-based compensation expense	(2,059)	3,151	2,694
Non-deductible compensation	901		1,864
Change in valuation allowance	50,834	3,241	55,173
Impact of the 2017 Tax Act		74,361
Other	(817)	(1,443)	1,330
Provision for income taxes	$ 0	$ 0	$ 0

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