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Note 10 - Income Taxes - Components of Deferred Tax Assets (Details) - USD ($) $ in Thousands	Dec. 31, 2018	Dec. 31, 2017
Deferred tax assets:
Net operating loss carryforward	$ 172,113	$ 134,659
Research and development credits	35,670	25,919
Stock-based compensation	11,905	8,633
Other	3,171	2,920
Total gross deferred tax assets	222,859	172,131
Valuation allowance	(222,859)	(172,131)
Net deferred tax assets

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards.

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