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Note 13 - Summary of Quarterly Consolidated Financial Data (Unaudited) - Summary Quarterly Results of Operations (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Revenues:
Net product sales	$ 28,844	$ 19,786	$ 17,277	$ 11,567	$ 10,053	$ 8,572	$ 8,510	$ 3,632	$ 77,474	$ 30,767	$ 1,279
Cost of product sales	(11,572)	(7,576)	(5,231)	(3,133)	(1,338)	(1,051)	(1,013)	(1,186)	(27,512)	(4,588)	(35)
Gross Profit	17,272	12,210	12,046	8,434	8,715	7,521	7,497	2,446
Operating expenses:
Research and development	39,891	30,421	30,159	39,561	47,757	28,844	28,597	33,384	140,032	138,582	103,125
General and administrative	8,738	7,288	6,209	7,028	6,165	6,462	6,185	6,742	29,263	25,554	21,366
Sales and marketing	19,957	16,281	14,531	13,835	16,683	13,529	14,770	11,619	64,604	56,601	47,668
Loss from operations	(51,314)	(41,780)	(38,853)	(51,990)	(61,890)	(41,314)	(42,055)	(49,299)
Other income (expense), net	1,755	3,434	183	(275)	(600)	(552)	(744)	(1,030)	5,097	(2,926)	(2,228)
Net loss	$ (49,559)	$ (38,346)	$ (38,670)	$ (52,265)	$ (62,490)	$ (41,866)	$ (42,799)	$ (50,329)	$ (178,840)	$ (197,484)	$ (173,143)
Basic and diluted net loss per share (in dollars per share)	$ (0.63)	$ (0.49)	$ (0.54)	$ (0.81)	$ (1.09)	$ (0.77)	$ (0.80)	$ (1)	$ (2.44)	$ (3.65)	$ (4.56)

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