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Note 3 - Accounting Policies (Tables)
3 Months Ended
Mar. 31, 2019
Notes Tables  
Schedules of Concentration of Risk, by Risk Factor [Table Text Block]
   
Net Product Sales
   
Accounts Receivable
 
   
Three Months
March 31, 2019
   
As of
March 31, 2019
 
                 
Customer A
   
40.7
%    
42.3
%
Customer B
   
36.6
%    
39.2
%
Customer C
   
20.4
%    
17.5
%
Total
   
97.7
%    
99.0
%
Valuation Allowances and Reserves [Table Text Block]
   
Product
Returns
   
Distributor
Fees
   
Discounts,
Rebates and
Administrative
Fees
   
Total
 
                                 
Balance at December 31, 2018
  $
947
    $
2,813
    $
21,743
    $
25,503
 
Provision
   
332
     
3,825
     
30,642
     
34,799
 
Payments/credits
   
(3
)    
(3,289
)    
(22,945
)    
(26,237
)
Balance at March 31, 2019
  $
1,276
    $
3,349
    $
29,440
    $
34,065
 
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
 
March 31
,
 
   
2019
   
2018
 
                 
Stock options outstanding
   
14,281
     
12,906
 
Warrants outstanding
   
640
     
640
 
Shares of common stock underlying Convertible Notes outstanding
   
8,600
     
8,103