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Note 4 - Fair Value Measurements - Financial Assets Measured on a Recurring Basis (Details) - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Available-for-sale securities	$ 265,777	$ 300,535
US Treasury Securities [Member]
Available-for-sale securities	89,283	59,741
Debt Security, Corporate, US [Member]
Available-for-sale securities	51,310	59,087
Debt Security, Corporate, Non-US [Member]
Available-for-sale securities	5,038	5,046
United States Commercial Paper [Member]
Available-for-sale securities	50,176	52,800
Foreign Commercial Paper [Member]
Available-for-sale securities	69,970	123,861
Fair Value, Recurring [Member]
Total	289,238	332,371
Fair Value, Recurring [Member] | Foreign Commercial Paper [Member]
Available-for-sale securities	69,970	123,861
Fair Value, Recurring [Member] | US Treasury Securities [Member]
Available-for-sale securities	89,283	59,741
Fair Value, Recurring [Member] | Debt Security, Corporate, US [Member]
Available-for-sale securities	51,310	59,087
Fair Value, Recurring [Member] | Debt Security, Corporate, Non-US [Member]
Available-for-sale securities	5,038	5,046
Fair Value, Recurring [Member] | United States Commercial Paper [Member]
Available-for-sale securities	50,176	61,885
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member]
Total	112,744	82,492
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | US Treasury Securities [Member]
Available-for-sale securities	89,283	59,741
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | Debt Security, Corporate, US [Member]
Available-for-sale securities
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | Debt Security, Corporate, Non-US [Member]
Available-for-sale securities
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | United States Commercial Paper [Member]
Available-for-sale securities
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | Foreign Commercial Paper [Member]
Available-for-sale securities
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member]
Total	176,494	249,879
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | US Treasury Securities [Member]
Available-for-sale securities
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | Debt Security, Corporate, US [Member]
Available-for-sale securities	51,310	59,087
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | Debt Security, Corporate, Non-US [Member]
Available-for-sale securities	5,038	5,046
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | United States Commercial Paper [Member]
Available-for-sale securities	50,176	61,885
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | Foreign Commercial Paper [Member]
Available-for-sale securities	69,970	123,861
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member]
Total
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | US Treasury Securities [Member]
Available-for-sale securities
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | Debt Security, Corporate, US [Member]
Available-for-sale securities
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | Debt Security, Corporate, Non-US [Member]
Available-for-sale securities
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | United States Commercial Paper [Member]
Available-for-sale securities
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | Foreign Commercial Paper [Member]
Available-for-sale securities
Fair Value, Recurring [Member] | Money Market Funds [Member]
Cash and money market funds	23,461	22,751
Fair Value, Recurring [Member] | Money Market Funds [Member] | Fair Value, Inputs, Level 1 [Member]
Cash and money market funds	23,461	22,751
Fair Value, Recurring [Member] | Money Market Funds [Member] | Fair Value, Inputs, Level 2 [Member]
Cash and money market funds
Fair Value, Recurring [Member] | Money Market Funds [Member] | Fair Value, Inputs, Level 3 [Member]
Cash and money market funds

X

- Definition

Fair value portion of probable future economic benefits obtained or controlled by an entity as a result of past transactions or events.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=117815213&loc=d3e19207-110258

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- Definition

Amount of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 326
-SubTopic 30
-Section 45
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=118942338&loc=SL82898722-210454

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-SubTopic 10
-Section 45
-Paragraph 1
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=118954083&loc=d3e26610-111562

Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (aa)
-URI http://asc.fasb.org/extlink&oid=118939692&loc=d3e27161-111563

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- Definition

Fair value portion of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.

+ References

No definition available.

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