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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Revenues:
Net product sales	$ 31,602	$ 11,567
Operating expenses:
Cost of product sales	14,962	3,133
Research and development	42,972	39,561
General and administrative	9,648	7,028
Sales and marketing	28,720	13,835
Total operating expenses	96,302	63,557
Loss from operations	(64,700)	(51,990)
Other income (expense), net	1,688	(275)
Net loss	(63,012)	(52,265)
Other comprehensive income (loss):
Unrealized gain (loss) on short-term investments	123	(32)
Comprehensive loss	$ (62,889)	$ (52,297)
Basic and diluted net loss per share (in dollars per share)	$ (0.80)	$ (0.81)
Shares used in computing basic and diluted net loss per share (in shares)	78,419	64,724

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