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Note 5 - Short-term Investments - Summary of Short-term Investments (Details) - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Available-for-sale securities, amortized cost	$ 265,741	$ 300,622
Available-for-sale securities, gross unrealized gains	39	5
Available-for-sale securities, gross unrealized losses	(3)	(92)
Available-for-sale securities	265,777	300,535
US Treasury Securities [Member]
Available-for-sale securities, amortized cost	89,255	59,747
Available-for-sale securities, gross unrealized gains	28
Available-for-sale securities, gross unrealized losses		(6)
Available-for-sale securities	89,283	59,741
Debt Security, Corporate, US [Member]
Available-for-sale securities, amortized cost	51,311	59,164
Available-for-sale securities, gross unrealized gains
Available-for-sale securities, gross unrealized losses	(1)	(77)
Available-for-sale securities	51,310	59,087
Debt Security, Corporate, Non-US [Member]
Available-for-sale securities, amortized cost	5,027	5,041
Available-for-sale securities, gross unrealized gains	11	5
Available-for-sale securities, gross unrealized losses
Available-for-sale securities	5,038	5,046
United States Commercial Paper [Member]
Available-for-sale securities, amortized cost	50,176	52,800
Available-for-sale securities, gross unrealized gains
Available-for-sale securities, gross unrealized losses
Available-for-sale securities	50,176	52,800
Foreign Commercial Paper [Member]
Available-for-sale securities, amortized cost	69,972	123,870
Available-for-sale securities, gross unrealized gains
Available-for-sale securities, gross unrealized losses	(2)	(9)
Available-for-sale securities	$ 69,970	$ 123,861

X

- Definition

Amount, before tax, of unrealized gain in accumulated other comprehensive income (AOCI) on investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

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