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Condensed Consolidated Statements of Stockholders' Equity (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
Common Stock [Member]
Additional Paid-in Capital [Member]
AOCI Attributable to Parent [Member]
Retained Earnings [Member]
Total
Balance (in shares) at Dec. 31, 2017 64,609        
Balance at Dec. 31, 2017 $ 646 $ 913,955 $ (10) $ (783,455) $ 131,136
Conversion benefit included in Convertible Notes issued 96 96
Issuance of common stock on exercise of stock options (in shares) 485        
Issuance of common stock on exercise of stock options $ 4 4,198 4,202
Stock-based compensation expense 7,701 7,701
Net loss (52,265) (52,265)
Unrealized gain (loss) on short-term investments (32) (32)
Comprehensive loss (52,297)
Cumulative effect of adoption of new accounting standard at Dec. 31, 2017 1,573 1,573
Issuance of common stock in public offerings, net (205) (205)
Balance (in shares) at Mar. 31, 2018 65,094        
Balance at Mar. 31, 2018 $ 650 925,745 (42) (834,147) 92,206
Balance (in shares) at Dec. 31, 2018 78,174        
Balance at Dec. 31, 2018 $ 782 1,330,186 (87) (960,721) 370,160
Conversion benefit included in Convertible Notes issued 102 $ 102
Issuance of common stock on exercise of stock options (in shares) 732       732
Issuance of common stock on exercise of stock options $ 7 6,532 $ 6,539
Stock-based compensation expense 17,902 17,902
Net loss (63,012) (63,012)
Unrealized gain (loss) on short-term investments 123 123
Comprehensive loss (62,889)
Balance (in shares) at Mar. 31, 2019 78,906        
Balance at Mar. 31, 2019 $ 789 $ 1,354,722 $ 36 $ (1,023,733) $ 331,814