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v3.19.3

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) | 9 Months Ended
--- | ---
Sep. 30, 2019 | Sep. 30, 2018
Operating activities: |  |
Net loss | $ (146,829,000) | $ (129,281,000)
Adjustments to reconcile net loss to net cash used for operating activities: |  |
Stock-based compensation expense | 40,312,000 | 23,572,000
Depreciation and amortization | 1,480,000 | 1,093,000
Amortization of debt discount | 780,000 | 654,000
Realized gain on short-term investments | (8,000) | 0
Accretion of discount on short-term investments | (3,264,000) | (1,920,000)
Impairment on property and equipment | 80,000 |
Loss on disposal of property and equipment | 53,000 | 3,000
Change in operating assets and liabilities: |  |
Accounts receivable | (2,303,000) | (11,759,000)
Prepaid expenses and other assets | (5,549,000) | (6,505,000)
Inventory | 14,860,000 | (21,502,000)
Accounts payable | (15,236,000) | (9,125,000)
Accrued clinical and manufacturing liabilities | 1,603,000 | (12,639,000)
Accrued payroll and employee liabilities | (3,263,000) | (403,000)
Other accrued liabilities | 19,681,000 | 9,494,000
Net cash used for operating activities | (97,603,000) | (158,318,000)
Investing activities: |  |
Purchases of short-term investments | (287,579,000) | (400,382,000)
Maturities and sales of short-term investments | 395,406,000 | 119,200,000
Purchases of property and equipment | (3,251,000) | (5,696,000)
Net cash provided by (used for) investing activities | 104,576,000 | (286,878,000)
Financing activities: |  |
Payments of stock issuance costs | (110,000) |
Net proceeds from sale of common stock |  | 363,128,000
Repayment of promissory note payable to related party |  | (25,000,000)
Proceeds from stock option exercises | 20,239,000 | 15,771,000
Proceeds from purchases under the Employee Stock Purchase Plan | 1,170,000 | 648,000
Net cash provided by financing activities | 21,299,000 | 354,547,000
Net increase (decrease) in cash and cash equivalents | 28,272,000 | (90,649,000)
Cash and cash equivalents at beginning of year | 31,836,000 | 144,583,000
Cash and cash equivalents at end of period | $ 60,108,000 | 53,934,000
Supplemental disclosure of cash flow information: |  |
Interest paid |  | 1,183,000
Cumulative effect of adoption of new accounting standard |  | $ 1,574,000

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- Definition Amount of cash inflow from sale, maturity, prepayment and call of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3151-108585 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3179-108585 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=118954083&loc=d3e26853-111562 + Details
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- Definition Amount of cash inflow from exercise of option under share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2A -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=116856206&loc=SL79508275-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3255-108585 + Details
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- Definition The cash outflow for a borrowing supported by a written promise to pay an obligation. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3291-108585 + Details
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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3602-108585 + Details
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