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Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Operating activities: |  |  |
Net loss | $ (204,749,000) | $ (178,840,000) | $ (197,484,000)
Adjustments to reconcile net loss to net cash used for operating activities: |  |  |
Stock-based compensation expense | 51,411,000 | 33,367,000 | 30,538,000
Depreciation and amortization | 2,044,000 | 1,513,000 | 1,531,000
Amortization of debt discount | 1,050,000 | 890,000 | 773,000
Accretion of discount on short-term investments | (3,730,000) | (3,412,000) | (278,000)
Realized gain on available-for-sale investments | (8,000) | 0 | 0
Impairment of property and equipment | 107,000 | 72,000 |
Loss on disposal of property and equipment | 62,000 | 29,000 | 39,000
Change in operating assets and liabilities: |  |  |
Accounts receivable | 24,773,000 | (22,778,000) | (39,914,000)
Prepaid expenses and other assets | (12,052,000) | (7,482,000) | 3,000
Inventory | 14,064,000 | (29,122,000) | (4,768,000)
Accounts payable | (14,105,000) | (1,906,000) | 11,955,000
Accrued clinical and manufacturing liabilities | 10,144,000 | (3,614,000) | 13,713,000
Accrued payroll and employee liabilities | 1,851,000 | 4,537,000 | 446,000
Deferred revenue |  |  | 1,664,000
Other accrued liabilities | 4,558,000 | 14,941,000 | 11,482,000
Net cash used for operating activities | (124,580,000) | (191,805,000) | (170,300,000)
Investing activities: |  |  |
Purchases of short-term investments | (477,035,000) | (497,104,000) | (121,570,000)
Maturities and sales of short-term investments | 462,406,000 | 227,700,000 | 131,783,000
Purchases of property and equipment | (7,154,000) | (9,171,000) | (2,553,000)
Proceeds from the sale of property and equipment |  | 25,000 | 78,000
Net cash (used for) provided by investing activities | (21,783,000) | (278,550,000) | 7,738,000
Financing activities: |  |  |
Net proceeds from sale of common stock and/or pre-funded warrants | 162,151,000 | 363,128,000 | 306,279,000
Proceeds from purchases under the Employee Stock Purchase Plan | 2,109,000 | 1,179,000 | 989,000
Proceeds from stock option exercises | 22,164,000 | 18,301,000 | 11,463,000
Proceeds from warrant exercises | 1,000 |  |
Repayment of promissory note payable to related party |  | (25,000,000) | (25,000,000)
Net cash provided by financing activities | 186,425,000 | 357,608,000 | 293,731,000
Net increase (decrease) in cash and cash equivalents | 40,062,000 | (112,747,000) | 131,169,000
Cash and cash equivalents at beginning of year | 31,836,000 | 144,583,000 | 13,414,000
Cash and cash equivalents at end of year | $ 71,898,000 | 31,836,000 | 144,583,000
Supplemental disclosure of cash flow information: |  |  |
Interest paid |  | 1,183,000 | $ 2,789,000
Cumulative effect of adoption of new accounting standard |  | $ 1,574,000 |

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- Definition Amount of cash inflow from sale, maturity, prepayment and call of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3151-108585 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3179-108585 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=118954083&loc=d3e26853-111562 + Details
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- Definition The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3179-108585 + Details
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- Definition Amount of cash inflow from exercise of option under share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2A -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=116856206&loc=SL79508275-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the amount received from holders exercising their stock warrants. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3255-108585 + Details
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- Definition The cash outflow for a borrowing supported by a written promise to pay an obligation. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3291-108585 + Details
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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3602-108585 + Details
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