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v3.20.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) | 3 Months Ended
--- | ---
Mar. 31, 2020 | Mar. 31, 2019
Operating activities: |  |
Net loss | $ (51,579,000) | $ (63,012,000)
Adjustments to reconcile net loss to net cash used for operating activities: |  |
Stock-based compensation expense | 11,974,000 | 17,902,000
Depreciation and amortization | 621,000 | 467,000
Amortization of debt discount | 310,000 | 247,000
Realized gain on available-for-sale securities | 0 | (8,000)
Accretion of discount on short-term investments | (117,000) | (1,357,000)
Impairment of property and equipment | 27,000 | 27,000
Loss on disposal of property and equipment |  | 52,000
Change in operating assets and liabilities: |  |
Accounts receivable | 5,068,000 | (9,355,000)
Prepaid expenses and other assets | 10,803,000 | (346,000)
Inventory | (9,881,000) | 7,611,000
Accounts payable | 8,804,000 | (6,052,000)
Accrued clinical and manufacturing liabilities | 707,000 | (868,000)
Accrued payroll and employee liabilities | (6,478,000) | (6,757,000)
Other accrued liabilities | (3,194,000) | 12,425,000
Net cash used for operating activities | (32,935,000) | (49,024,000)
Investing activities: |  |
Purchases of short-term investments | (28,922,000) | (127,763,000)
Maturities and sales of short-term investments | 95,675,000 | 164,009,000
Purchases of property and equipment | (2,938,000) | (2,136,000)
Net cash provided by investing activities | 63,815,000 | 34,110,000
Financing activities: |  |
Proceeds from stock option exercises | 504,000 | 6,539,000
Proceeds from warrant exercises | 3,000 |
Net cash provided by financing activities | 507,000 | 6,539,000
Net increase (decrease) in cash and cash equivalents | 31,387,000 | (8,375,000)
Cash and cash equivalents at beginning of year | 71,898,000 | 31,836,000
Cash and cash equivalents at end of period | $ 103,285,000 | $ 23,461,000

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