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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2020
Jun. 30, 2019
Jun. 30, 2020
Jun. 30, 2019
Revenues:        
Net product sales $ 22,668 $ 36,659 $ 48,068 $ 68,261
Operating expenses:        
Cost of product sales 9,005 13,588 19,627 28,550
Research and development 44,004 41,425 80,898 84,397
General and administrative 9,819 9,778 20,241 19,426
Sales and marketing 15,589 23,647 35,785 52,367
Total operating expenses 78,417 88,438 156,551 184,740
Loss from operations (55,749) (51,779) (108,483) (116,479)
Other income, net 559 1,557 1,714 3,245
Net loss (55,190) (50,222) (106,769) (113,234)
Other comprehensive income:        
Unrealized gains on short-term investments 245 112 868 235
Comprehensive loss $ (54,945) $ (50,110) $ (105,901) $ (112,999)
Basic and diluted net loss per share $ (0.61) $ (0.63) $ (1.18) $ (1.43)
Shares used in computing basic and diluted net loss per share 90,753 79,548 90,581 78,987