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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Revenues:        
Net product sales $ 19,965 $ 42,624 $ 68,033 $ 110,885
Operating expenses:        
Cost of product sales 7,170 17,195 26,797 45,745
Research and development 49,182 34,708 130,080 119,105
General and administrative 9,482 8,597 29,723 28,023
Sales and marketing 12,515 16,977 48,300 69,344
Total operating expenses 78,349 77,477 234,900 262,217
Loss from operations (58,384) (34,853) (166,867) (151,332)
Other income, net 156 1,258 1,870 4,503
Net loss (58,228) (33,595) (164,997) (146,829)
Other comprehensive (loss) income:        
Unrealized (losses) gains on short-term investments (413) (45) 455 190
Comprehensive loss $ (58,641) $ (33,640) $ (164,542) $ (146,639)
Basic and diluted net loss per share $ (0.64) $ (0.42) $ (1.82) $ (1.85)
Shares used in computing basic and diluted net loss per share 90,849 79,940 90,671 79,308