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Stockholders' Equity - Summary of Stock-Based Compensation Expense related to Stock-Based Payment Awards Granted (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Stock-based compensation expense $ 11,095 $ 9,704 $ 34,183 $ 40,312
Research and Development Expense        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Stock-based compensation expense 4,612 4,365 14,580 14,123
General and Administrative Expense        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Stock-based compensation expense 3,277 2,939 10,012 10,333
Selling and Marketing Expense        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Stock-based compensation expense $ 3,206 $ 2,400 $ 9,591 $ 15,856