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Summary of Significant Accounting Policies - Additional Information (Details) - USD ($) $ in Thousands |  | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Jan. 01, 2018 | Dec. 31, 2020 | Sep. 30, 2020 | Jun. 30, 2020 | Mar. 31, 2020 | Dec. 31, 2019 | Sep. 30, 2019 | Jun. 30, 2019 | Mar. 31, 2019 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Product Information [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Cumulative adjustment to accumulated deficit |  | $ (1,392,748) |  |  |  | $ (1,165,470) |  |  |  | $ (1,392,748) | $ (1,165,470) |
Product sales allowances |  | 24,571 |  |  |  | 27,939 |  |  |  | 24,571 | 27,939 |
Cost of product sales |  | $ 9,392 | $ 7,170 | $ 9,005 | $ 10,622 | $ 15,874 | $ 17,195 | $ 13,588 | $ 14,962 | $ 36,189 | $ 61,619 | $ 27,512
Accounting Standards Update 2014-09 |  |  |  |  |  |  |  |  |  |  |  |
Product Information [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Gross product sales | $ 2,900 |  |  |  |  |  |  |  |  |  |  |
Cost of product sales | 200 |  |  |  |  |  |  |  |  |  |  |
Accounting Standards Update 2014-09 | Product Sales Allowance |  |  |  |  |  |  |  |  |  |  |  |
Product Information [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Product sales allowances | 1,100 |  |  |  |  |  |  |  |  |  |  |
Accounting Standards Update 2018-13 |  |  |  |  |  |  |  |  |  |  |  |
Product Information [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Change in accounting principle, accounting standards update, adopted |  | true |  |  |  |  |  |  |  | true |  |
Change in accounting principle, accounting standards update, immaterial effect |  | true |  |  |  |  |  |  |  | true |  |
Accounting Standards Update 2016-13 |  |  |  |  |  |  |  |  |  |  |  |
Product Information [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Change in accounting principle, accounting standards update, adopted |  | true |  |  |  |  |  |  |  | true |  |
Change in accounting principle, accounting standards update, immaterial effect |  | true |  |  |  |  |  |  |  | true |  |
Change in accounting principle, accounting standards update, adoption date |  | Jan. 01, 2020 |  |  |  |  |  |  |  | Jan. 01, 2020 |  |
Cumulative Effect Period of Adoption Adjustment | Accounting Standards Update 2014-09 |  |  |  |  |  |  |  |  |  |  |  |
Product Information [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Cumulative adjustment to accumulated deficit | $ (1,600) |  |  |  |  |  |  |  |  |  |  |
Leasehold Improvements |  |  |  |  |  |  |  |  |  |  |  |
Product Information [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Estimated useful lives |  |  |  |  |  |  |  |  |  | 5 years |  |

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