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v3.20.4

Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Operating activities: |  |  |
Net loss | $ (227,278,000) | $ (204,749,000) | $ (178,840,000)
Adjustments to reconcile net loss to net cash used for operating activities: |  |  |
Stock-based compensation expense | 50,218,000 | 51,411,000 | 33,367,000
Depreciation and amortization | 2,847,000 | 2,044,000 | 1,513,000
Amortization of debt discount | 1,429,000 | 1,050,000 | 890,000
Amortization of premium (accretion of discount) on short-term investments | 125,000 | (3,730,000) | (3,412,000)
Realized gain on available-for-sale investments | 0 | (8,000) | 0
Impairment of property and equipment | 847,000 | 107,000 | 72,000
Loss on disposal of property and equipment |  | 62,000 | 29,000
Change in operating assets and liabilities: |  |  |
Accounts receivable | (1,971,000) | 24,773,000 | (22,778,000)
Inventory | (16,937,000) | 14,064,000 | (29,122,000)
Prepaid expenses and other assets | 1,295,000 | (12,052,000) | (7,482,000)
Accounts payable | (2,233,000) | (14,105,000) | (1,906,000)
Accrued clinical and manufacturing liabilities | 15,348,000 | 10,144,000 | (3,614,000)
Accrued payroll and employee liabilities | (1,651,000) | 1,851,000 | 4,537,000
Other accrued liabilities | (6,859,000) | 4,558,000 | 14,941,000
Net cash used for operating activities | (184,820,000) | (124,580,000) | (191,805,000)
Investing activities: |  |  |
Purchases of short-term investments | (134,007,000) | (477,035,000) | (497,104,000)
Maturities and sales of short-term investments | 349,775,000 | 462,406,000 | 227,700,000
Purchases of property and equipment | (6,813,000) | (7,154,000) | (9,171,000)
Proceeds from the sale of property and equipment |  |  | 25,000
Net cash provided by (used for) investing activities | 208,955,000 | (21,783,000) | (278,550,000)
Financing activities: |  |  |
Net proceeds from sale of common stock and/or pre-funded warrants |  | 162,151,000 | 363,128,000
Proceeds from purchases under the Employee Stock Purchase Plan | 2,317,000 | 2,109,000 | 1,179,000
Proceeds from stock option exercises | 6,759,000 | 22,164,000 | 18,301,000
Proceeds from conversion of convertible notes payable | 26,000 |  |
Proceeds from warrant exercises | 3,000 | 1,000 |
Repayment of promissory note payable to related party |  |  | (25,000,000)
Net cash provided by financing activities | 9,105,000 | 186,425,000 | 357,608,000
Net increase (decrease) in cash and cash equivalents | 33,240,000 | 40,062,000 | (112,747,000)
Cash and cash equivalents at beginning of year | 71,898,000 | 31,836,000 | 144,583,000
Cash and cash equivalents at end of year | $ 105,138,000 | $ 71,898,000 | 31,836,000
Supplemental disclosure of cash flow information: |  |  |
Interest paid |  |  | 1,183,000
Cumulative effect of adoption of new accounting standard |  |  | $ 1,574,000

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