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Stockholders' Equity (Tables)

12 Months Ended

Dec. 31, 2020

Equity [Abstract]

Summary of Common Stock Reserved for Future Issuance

Shares of our common stock reserved for future issuance as of December 31, 2020 were as follows:

		Number of
		Shares
Stock options outstanding			18,912,529
Restricted stock units outstanding			602,741
Stock options available for grant			1,575,955
Employee Stock Purchase Plan			176,250
Warrants outstanding			220,164
Shares of common stock underlying Convertible Notes outstanding (see Note 8)			9,510,208
Total shares reserved for future issuance			30,997,847

Summary of Stock Option Plan Activity (Including Restricted Stock Units)

The following table summarizes the stock option plan activity (including RSUs):

		Outstanding Options
						Weighted-
						Average
		Number of				Exercise
		Shares				Price
Balance at December 31, 2017			13,462,964			$	15.03
Granted			4,052,011			$	26.83
Exercised			(1,529,509	)		$	11.97
Cancelled			(720,859	)		$	17.98
Balance at December 31, 2018			15,264,607			$	18.33
Granted			4,933,480			$	24.21
Exercised			(1,983,221	)		$	11.18
Cancelled			(1,550,226	)		$	23.26
Balance at December 31, 2019			16,664,640			$	20.47
Granted			4,659,942			$	13.95
Exercised			(544,441	)		$	12.41
Cancelled			(1,264,871	)		$	22.84
Balance at December 31, 2020			19,515,270			$	18.98

Schedule of Options Exercisable, Vested or Expected to Vest

		Years Ended December 31,
		2020								2019								2018
						Weighted-								Weighted-								Weighted-
						Average								Average								Average
						Exercise								Exercise								Exercise
		Options				Price				Options				Price				Options				Price
Exercisable at end of year			10,237,202			$	18.74				7,436,379			$	17.02				6,523,093			$	14.83
Options vested or expected to vest			18,179,553			$	19.58				15,962,432			$	20.31				14,449,017			$	18.11

Schedule of Exercise Prices And Weighted-average Remaining Contractual Lives For Options Outstanding

Exercise prices and weighted-average remaining contractual lives for the options outstanding as of December 31, 2020 were:

																		Weighted-
						Weighted-												Average
						Average				Weighted-								Exercise
						Remaining				Average								Price of
Options				Range of		Contractual				Exercise				Options				Options
Outstanding				Exercise Prices		Life (in years)				Price				Exercisable				Exercisable
	2,700,473			$5.20–$13.00			3.97			$	10.14				2,691,327			$	10.14
	800,371			$13.05–$15.55			6.13				14.31				655,173				14.22
	3,582,407			$15.72			9.75				15.72				149,197				15.72
	2,838,033			$15.78–$17.89			6.10				16.87				2,348,090				16.84
	3,688,255			$18.00–$24.97			7.15				22.97				2,036,430				23.10
	3,498,912			$25.02			8.63				25.02				1,010,859				25.02
	1,804,078			$25.06–$39.00			6.64				30.58				1,346,126				30.43
	18,912,529						7.21				19.59				10,237,202				18.74

Summary of Stock-Based Compensation Expense related to Stock-Based Payment Awards

The following table summarizes stock-based compensation expense related to stock-based payment awards pursuant to our equity compensation arrangements (in thousands):

		December 31,
		2020				2019				2018
Research and development		$	20,731			$	19,202			$	13,689
General and administrative			15,601				13,564				9,630
Sales and marketing			13,886				18,645				10,048
Total stock-based compensation expense		$	50,218			$	51,411			$	33,367

Summary of Fair Value of Option Grant and ESPP Purchase Right on Grant Date Using Black-Scholes Option Pricing Model

We estimated the fair value of each option grant and ESPP purchase right on the date of grant using the Black-Scholes option pricing model with the following weighted-average assumptions:

Options:

		December 31,
		2020				2019				2018
Risk-free interest rate			0.5	%			1.8	%			2.8	%
Dividend yield			—	%			—	%			—	%
Volatility			69.4	%			66.5	%			70.4	%
Expected life (years)			6				6				6

ESPP:

		December 31,
		2020				2019				2018
Risk-free interest rate			0.1	%			1.9	%			2.4	%
Dividend yield			—	%			—	%			—	%
Volatility			67.7	%			52.1	%			59.7	%
Expected life (months)			6				6				6

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