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Consolidated Statements of Operations and Comprehensive Loss - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Revenues:      
Net product sales $ 88,638 $ 145,968 $ 77,474
Operating expenses:      
Cost of product sales 36,189 61,619 27,512
Research and development 174,533 167,382 140,032
General and administrative 42,226 37,897 29,263
Sales and marketing 63,853 89,764 64,604
Total operating expenses 316,801 356,662 261,411
Loss from operations (228,163) (210,694) (183,937)
Other income, net:      
Interest income 3,633 7,259 5,965
Interest expense (1,901) (1,472) (2,672)
Other income (expense) (847) 158 1,804
Total other income, net 885 5,945 5,097
Net loss (227,278) (204,749) (178,840)
Other comprehensive income (loss):      
Unrealized gains (losses) on short-term investments 172 172 (77)
Comprehensive loss $ (227,106) $ (204,577) $ (178,917)
Basic and diluted net loss per share $ (2.50) $ (2.50) $ (2.44)
Shares used in computing basic and diluted net loss per share 90,774 81,779 73,193