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Consolidated Statements of Stockholders' Equity - USD ($)
shares in Thousands, $ in Thousands
Total
Cumulative Effect Period of Adoption Adjustment
Common Stock
Additional Paid-In Capital
Accumulated Other Comprehensive (Loss) Income
Accumulated Deficit
Accumulated Deficit
Cumulative Effect Period of Adoption Adjustment
Balance at Dec. 31, 2017 $ 131,136 $ 1,574 $ 646 $ 913,955 $ (10) $ (783,455) $ 1,574
Balance (in shares) at Dec. 31, 2017     64,609        
Issuance of common stock in public offerings, net 363,128   $ 120 363,008      
Issuance of common stock in public offerings, net (in shares)     11,963        
Conversion benefit included in Convertible Notes issued 392     392      
Issuance of common stock under Employee Stock Purchase Plan 1,179   $ 1 1,178      
Issuance of common stock under Employee Stock Purchase Plan (in shares)     72        
Issuance of common stock on exercise of stock options 18,301   $ 15 18,286      
Issuance of common stock on exercise of stock options (in shares)     1,530        
Stock-based compensation expense 33,367     33,367      
Net loss (178,840)         (178,840)  
Net unrealized gain (loss) on short-term investments (77)       (77)    
Comprehensive loss (178,917)            
Balance at Dec. 31, 2018 370,160   $ 782 1,330,186 (87) (960,721)  
Balance (in shares) at Dec. 31, 2018     78,174        
Issuance of common stock in public offerings, net 162,151   $ 99 162,052      
Issuance of common stock in public offerings, net (in shares)     9,857        
Conversion benefit included in Convertible Notes issued 416     416      
Issuance of common stock under Employee Stock Purchase Plan 2,109   $ 1 2,108      
Issuance of common stock under Employee Stock Purchase Plan (in shares)     126        
Issuance of common stock on exercise of stock options 22,164   $ 20 22,144      
Issuance of common stock on exercise of stock options (in shares)     1,983        
Issuance of common stock on exercise of warrants 1   $ 1        
Issuance of common stock on exercise of warrants (in shares)     132        
Issuance of common stock on conversion of convertible notes (in shares)     32        
Stock-based compensation expense 51,411     51,411      
Net loss (204,749)         (204,749)  
Net unrealized gain (loss) on short-term investments 172       172    
Comprehensive loss (204,577)            
Balance at Dec. 31, 2019 403,835   $ 903 1,568,317 85 (1,165,470)  
Balance (in shares) at Dec. 31, 2019     90,304        
Conversion benefit included in Convertible Notes issued 440     440      
Issuance of common stock under Employee Stock Purchase Plan 2,317   $ 2 2,315      
Issuance of common stock under Employee Stock Purchase Plan (in shares)     194        
Issuance of common stock on exercise of stock options 6,759   $ 5 6,754      
Issuance of common stock on exercise of stock options (in shares)     545        
Issuance of common stock on exercise of warrants 3   $ 3        
Issuance of common stock on exercise of warrants (in shares)     267        
Issuance of common stock on conversion of Convertible Notes 26     26      
Stock-based compensation expense 50,218     50,218      
Net loss (227,278)         (227,278)  
Net unrealized gain (loss) on short-term investments 172       172    
Comprehensive loss (227,106)            
Balance at Dec. 31, 2020 $ 236,492   $ 913 $ 1,628,070 $ 257 $ (1,392,748)  
Balance (in shares) at Dec. 31, 2020     91,310