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Summary of Quarterly Consolidated Financial Data (Unaudited) - Summary of Unaudited Quarterly Results of Operations (Details) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2020
Sep. 30, 2020
Jun. 30, 2020
Mar. 31, 2020
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Revenues:                      
Net product sales $ 20,605 $ 19,965 $ 22,668 $ 25,400 $ 35,083 $ 42,624 $ 36,659 $ 31,602 $ 88,638 $ 145,968 $ 77,474
Cost of product sales (9,392) (7,170) (9,005) (10,622) (15,874) (17,195) (13,588) (14,962) (36,189) (61,619) (27,512)
Gross Profit 11,213 12,795 13,663 14,778 19,209 25,429 23,071 16,640      
Operating expenses:                      
Research and development 44,453 49,182 44,004 36,894 48,277 34,708 41,425 42,972 174,533 167,382 140,032
General and administrative 12,503 9,482 9,819 10,422 9,874 8,597 9,778 9,648 42,226 37,897 29,263
Sales and marketing 15,553 12,515 15,589 20,196 20,420 16,977 23,647 28,720 63,853 89,764 64,604
Loss from operations (61,296) (58,384) (55,749) (52,734) (59,362) (34,853) (51,779) (64,700) (228,163) (210,694) (183,937)
Other income (expense), net (985) 156 559 1,155 1,442 1,258 1,557 1,688 885 5,945 5,097
Net loss $ (62,281) $ (58,228) $ (55,190) $ (51,579) $ (57,920) $ (33,595) $ (50,222) $ (63,012) $ (227,278) $ (204,749) $ (178,840)
Basic and diluted net loss per share $ (0.68) $ (0.64) $ (0.61) $ (0.57) $ (0.65) $ (0.42) $ (0.63) $ (0.80) $ (2.50) $ (2.50) $ (2.44)