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v3.21.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2021 | Mar. 31, 2020
Operating activities: |  |
Net loss | $ (52,614) | $ (51,579)
Adjustments to reconcile net loss to net cash used for operating activities: |  |
Stock-based compensation expense | 11,486 | 11,974
Depreciation and amortization | 739 | 621
Amortization of debt discount | 502 | 310
Amortization of premium (accretion of discount) on short-term investments | 48 | (117)
Impairment of property and equipment | 80 | 27
Change in operating assets and liabilities: |  |
Accounts receivable | 3,325 | 5,068
Prepaid expenses and other assets | (2,718) | 10,803
Inventory | (724) | (9,881)
Accounts payable | 1,164 | 8,804
Accrued clinical and manufacturing liabilities | 4,257 | 707
Accrued payroll and employee liabilities | (3,968) | (6,478)
Other accrued liabilities | (3,515) | (3,194)
Net cash used for operating activities | (41,938) | (32,935)
Investing activities: |  |
Purchases of short-term investments | (44,058) | (28,922)
Maturities and sales of short-term investments | 40,500 | 95,675
Purchases of property and equipment | (786) | (2,938)
Net cash (used for) provided by investing activities | (4,344) | 63,815
Financing activities: |  |
Proceeds from issuance of common stock under equity incentive plan | 883 | 504
Proceeds from warrant exercises |  | 3
Net cash provided by financing activities | 883 | 507
Net (decrease) increase in cash and cash equivalents | (45,399) | 31,387
Cash and cash equivalents at beginning of year | 105,138 | 71,898
Cash and cash equivalents at end of period | $ 59,739 | $ 103,285

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- Definition The cash inflow associated with the amount received from holders exercising their stock warrants. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=121586364&loc=d3e3255-108585 + Details
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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=121586364&loc=d3e3602-108585 + Details
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