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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended
Mar. 31, 2021
Mar. 31, 2020
Revenues:    
Net product sales $ 20,018 $ 25,400
Operating expenses:    
Cost of product sales 9,207 10,622
Research and development 38,116 36,894
General and administrative 9,573 10,422
Sales and marketing 15,236 20,196
Total operating expenses 72,132 78,134
Loss from operations (52,114) (52,734)
Other income (expense) (500) 1,155
Net loss (52,614) (51,579)
Other comprehensive income (loss):    
Unrealized gains (losses) on short-term investments (136) 623
Comprehensive loss $ (52,750) $ (50,956)
Basic and diluted net loss per share $ (0.58) $ (0.57)
Shares used in computing basic and diluted net loss per share 91,388 90,409