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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Revenues:        
Net product sales $ 22,443 $ 22,668 $ 42,461 $ 48,068
Operating expenses:        
Cost of product sales 14,522 9,005 23,729 19,627
Research and development 35,233 44,004 73,349 80,898
General and administrative 10,907 9,819 20,480 20,241
Sales and marketing 22,250 15,589 37,486 35,785
Total operating expenses 82,912 78,417 155,044 156,551
Loss from operations (60,469) (55,749) (112,583) (108,483)
Other income (expense) (546) 559 (1,046) 1,714
Net loss (61,015) (55,190) (113,629) (106,769)
Other comprehensive income (loss):        
Unrealized gains (losses) on short-term investments (80) 245 (216) 868
Comprehensive loss $ (61,095) $ (54,945) $ (113,845) $ (105,901)
Basic and diluted net loss per share $ (0.62) $ (0.61) $ (1.20) $ (1.18)
Shares used in computing basic and diluted net loss per share 98,459 90,753 94,943 90,581