    <SEC-DOCUMENT>0001564590-21-020111-index.html : 20210422
    <SEC-HEADER>0001564590-21-020111.hdr.sgml : 20210422
    <ACCEPTANCE-DATETIME>20210422161522
    ACCESSION NUMBER:		0001564590-21-020111
    CONFORMED SUBMISSION TYPE:	DEFA14A
    PUBLIC DOCUMENT COUNT:		3
    FILED AS OF DATE:		20210422
    DATE AS OF CHANGE:		20210422

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			HERON THERAPEUTICS, INC. /DE/
    		CENTRAL INDEX KEY:			0000818033
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				942875566
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEFA14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-33221
    		FILM NUMBER:		21844964

    	BUSINESS ADDRESS:
    		STREET 1:		4242 CAMPUS POINT COURT, SUITE 200
    		CITY:			SAN DIEGO
    		STATE:			CA
    		ZIP:			92121
    		BUSINESS PHONE:		8582514400

    	MAIL ADDRESS:
    		STREET 1:		4242 CAMPUS POINT COURT, SUITE 200
    		CITY:			SAN DIEGO
    		STATE:			CA
    		ZIP:			92121

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	AP PHARMA INC /DE/
    		DATE OF NAME CHANGE:	20010511

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	ADVANCED POLYMER SYSTEMS INC /DE/
    		DATE OF NAME CHANGE:	19920703
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEFA14A
    <SEQUENCE>1
    <FILENAME>hrtx-defa14a_20210617.htm
    <DESCRIPTION>DEFA14A
    <TEXT>
    Document 1 - file: hrtx-defa14a_20210617.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>gu3o05rk1mxn000001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: gu3o05rk1mxn000001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>gu3o05rk1mxn000002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: gu3o05rk1mxn000002.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>