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Income Taxes - Schedule of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforward | $ 294,189 | $ 251,971
Research and development credits | 55,789 | 49,683
Stock-based compensation | 23,342 | 20,211
Lease liabilities | 2,564 | 4,330
Other | 3,953 | 3,777
Total gross deferred tax assets | 379,837 | 329,972
Deferred tax liabilities: |  |
Right-of-use lease assets | (2,420) | (4,014)
Total gross deferred tax liabilities | (2,420) | (4,014)
Valuation allowance | $ (377,417) | $ (325,958)

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