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v3.22.0.1

Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Operating activities: |  |  |
Net loss | $ (220,683,000) | $ (227,278,000) | $ (204,749,000)
Adjustments to reconcile net loss to net cash used for operating activities: |  |  |
Stock-based compensation expense | 46,851,000 | 50,218,000 | 51,411,000
Depreciation and amortization | 3,021,000 | 2,847,000 | 2,044,000
Amortization of debt discount | 785,000 | 1,429,000 | 1,050,000
Amortization of debt issuance costs | 119,000 |  |
Amortization of premium (accretion of discount) on short-term investments | 332,000 | 125,000 | (3,730,000)
Realized gain on available-for-sale investments | 0 | 0 | (8,000)
Impairment of property and equipment | 478,000 | 847,000 | 107,000
Loss on disposal of property and equipment | 822,000 |  | 62,000
Change in operating assets and liabilities: |  |  |
Accounts receivable | 6,351,000 | (1,971,000) | 24,773,000
Inventory | (6,477,000) | (16,937,000) | 14,064,000
Prepaid expenses and other assets | (8,386,000) | 1,295,000 | (12,052,000)
Accounts payable | 3,278,000 | (2,233,000) | (14,105,000)
Accrued clinical and manufacturing liabilities | (26,246,000) | 15,348,000 | 10,144,000
Accrued payroll and employee liabilities | 1,666,000 | (1,651,000) | 1,851,000
Other accrued liabilities | (5,265,000) | (6,859,000) | 4,558,000
Net cash used for operating activities | (203,354,000) | (184,820,000) | (124,580,000)
Investing activities: |  |  |
Purchases of short-term investments | (129,221,000) | (134,007,000) | (477,035,000)
Maturities and sales of short-term investments | 164,940,000 | 349,775,000 | 462,406,000
Purchases of property and equipment | (3,022,000) | (6,813,000) | (7,154,000)
Proceeds from the sale of property and equipment | 32,000 |  |
Net cash provided by (used for) investing activities | 32,729,000 | 208,955,000 | (21,783,000)
Financing activities: |  |  |
Net proceeds from sale of common stock |  |  | 162,151,000
Net proceeds from convertible notes financing | 148,963,000 |  |
Proceeds from purchases under the Employee Stock Purchase Plan | 2,139,000 | 2,317,000 | 2,109,000
Proceeds from stock issued under the equity incentive plan | 4,926,000 | 6,759,000 | 22,164,000
Proceeds from conversion of convertible notes payable |  | 26,000 |
Proceeds from warrant exercises |  | 3,000 | 1,000
Net cash provided by financing activities | 156,028,000 | 9,105,000 | 186,425,000
Net increase (decrease) in cash and cash equivalents | (14,597,000) | 33,240,000 | 40,062,000
Cash and cash equivalents at beginning of year | 105,138,000 | 71,898,000 | 31,836,000
Cash and cash equivalents at end of year | 90,541,000 | $ 105,138,000 | $ 71,898,000
Supplemental disclosure of cash flow information: |  |  |
Interest paid | $ 1,244,000 |  |

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