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v3.22.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2022 | Mar. 31, 2021
Operating activities: |  |
Net loss | $ (63,888) | $ (52,614)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Stock-based compensation expense | 10,915 | 11,486
Depreciation and amortization | 721 | 739
Amortization of debt discount |  | 502
Amortization of debt issuance costs | 50 |
Amortization of premium on short-term investments | 104 | 48
Impairment of property and equipment | 47 | 80
Loss on disposal of property and equipment | 96 |
Change in operating assets and liabilities: |  |
Accounts receivable | (5,604) | 3,325
Inventory | (8,088) | (724)
Prepaid expenses and other assets | (405) | (2,718)
Accounts payable | 4,423 | 1,164
Accrued clinical and manufacturing liabilities | 13,561 | 4,257
Accrued payroll and employee liabilities | (3,049) | (3,968)
Other accrued and other non-current liabilities | 7,178 | (3,515)
Net cash used in operating activities | (43,939) | (41,938)
Investing activities: |  |
Purchases of short-term investments | (38,023) | (44,058)
Maturities and sales of short-term investments | 49,957 | 40,500
Purchases of property and equipment | (1,044) | (786)
Proceeds from the sale of property and equipment | 56 |
Net cash provided by (used in) investing activities | 10,946 | (4,344)
Financing activities: |  |
Net proceeds from issuance of common stock under equity incentive plan | (637) | 883
Net cash (used in) provided by financing activities | (637) | 883
Net decrease in cash and cash equivalents | (33,630) | (45,399)
Cash and cash equivalents at beginning of year | 90,541 | 105,138
Cash and cash equivalents at end of period | $ 56,911 | $ 59,739

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