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v3.22.2

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2022 | Jun. 30, 2021
Operating activities: |  |
Net loss | $ (120,247) | $ (113,629)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Stock-based compensation expense | 21,268 | 22,727
Depreciation and amortization | 1,392 | 1,473
Amortization of debt discount |  | 785
Amortization of debt issuance costs | 100 |
Amortization of premium on short-term investments | 93 | 178
Impairment of property and equipment | 88 | 190
Loss on disposal of property and equipment | 96 |
Change in operating assets and liabilities: |  |
Accounts receivable | (4,804) | (765)
Inventory | (12,936) | (895)
Prepaid expenses and other assets | 4,098 | (1,783)
Accounts payable | 10,001 | 10,717
Accrued clinical and manufacturing liabilities | 19,954 | (26,055)
Accrued payroll and employee liabilities | 1,060 | 84
Other accrued and other non-current liabilities | 7,525 | 2,043
Net cash used in operating activities | (72,312) | (104,930)
Investing activities: |  |
Purchases of short-term investments | (58,945) | (62,046)
Maturities and sales of short-term investments | 90,957 | 98,500
Purchases of property and equipment | (1,366) | (1,101)
Proceeds from the sale of property and equipment | 56 |
Net cash provided by investing activities | 30,702 | 35,353
Financing activities: |  |
Net proceeds from convertible note financing |  | 148,982
Net proceeds from issuance of common stock under equity incentive plan | (1,094) | 5,101
Proceeds from purchases under the employee stock purchase plan | 772 | 1,529
Net cash (used in) provided by financing activities | (322) | 155,612
Net (decrease) increase in cash and cash equivalents | (41,932) | 86,035
Cash and cash equivalents at beginning of year | 90,541 | 105,138
Cash and cash equivalents at end of period | 48,609 | $ 191,173
Supplemental disclosure of cash flow information: |  |
Interest paid | $ 1,125 |

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