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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Revenues:        
Net product sales $ 27,630 $ 22,443 $ 51,087 $ 42,461
Operating expenses:        
Cost of product sales 16,175 14,522 27,530 23,729
Research and development 28,834 35,233 70,904 73,349
General and administrative 9,181 10,907 18,714 20,480
Sales and marketing 22,938 22,250 46,360 37,486
Total operating expenses 77,128 82,912 163,508 155,044
Loss from operations (49,498) (60,469) (112,421) (112,583)
Other expense, net (6,861) (546) (7,826) (1,046)
Net loss (56,359) (61,015) (120,247) (113,629)
Other comprehensive loss:        
Unrealized losses on short-term investments (3) (80) (5) (216)
Comprehensive loss $ (56,362) $ (61,095) $ (120,252) $ (113,845)
Basic net loss per share $ (0.55) $ (0.62) $ (1.18) $ (1.20)
Diluted net loss per share $ (0.55) $ (0.62) $ (1.18) $ (1.20)
Shares used in computing basic net loss per share 102,405 98,459 102,265 94,943
Shares used in computing diluted net loss per share 102,405 98,459 102,265 94,943