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Condensed Consolidated Statements of Stockholders' Equity (Deficit) (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
Total
Common Stock
Additional Paid-In Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Balance at Dec. 31, 2020 $ 236,492 $ 913 $ 1,628,070 $ 257 $ (1,392,748)
Balance (in shares) at Dec. 31, 2020   91,310      
Conversion benefit included in Convertible Notes issued 114   114    
Issuance of common stock under equity incentive plan 883 $ 1 882    
Issuance of common stock under equity incentive plan (in shares)   97      
Stock-based compensation expense 11,486   11,486    
Net loss (52,614)       (52,614)
Net unrealized loss on short-term investments (136)     (136)  
Comprehensive loss (52,750)        
Balance at Mar. 31, 2021 196,225 $ 914 1,640,552 121 (1,445,362)
Balance (in shares) at Mar. 31, 2021   91,407      
Balance at Dec. 31, 2020 236,492 $ 913 1,628,070 257 (1,392,748)
Balance (in shares) at Dec. 31, 2020   91,310      
Net loss (113,629)        
Net unrealized loss on short-term investments (216)        
Comprehensive loss (113,845)        
Balance at Jun. 30, 2021 160,112 $ 1,019 1,665,429 41 (1,506,377)
Balance (in shares) at Jun. 30, 2021   101,874      
Balance at Mar. 31, 2021 196,225 $ 914 1,640,552 121 (1,445,362)
Balance (in shares) at Mar. 31, 2021   91,407      
Conversion benefit included in Convertible Notes issued 116   116    
Issuance of common stock under equity incentive plan 4,218 $ 4 4,214    
Issuance of common stock under equity incentive plan (in shares)   313      
Issuance of common stock on under the employee stock purchase plan 1,529 $ 1 1,528    
Issuance of common stock on under the employee stock purchase plan (in shares)   110      
Issuance of common stock on exercise of warrants   $ 2 (2)    
Issuance of common stock on exercise of warrants (in shares)   195      
Issuance of common stock on conversion of notes 7,878 $ 98 7,780    
Issuance of common stock on conversion of notes (in shares)   9,849      
Stock-based compensation expense 11,241   11,241    
Net loss (61,015)       (61,015)
Net unrealized loss on short-term investments (80)     (80)  
Comprehensive loss (61,095)        
Balance at Jun. 30, 2021 160,112 $ 1,019 1,665,429 41 (1,506,377)
Balance (in shares) at Jun. 30, 2021   101,874      
Balance at Dec. 31, 2021 77,570 $ 1,020 1,689,987 (6) (1,613,431)
Balance (in shares) at Dec. 31, 2021   102,005      
Issuance of common stock under equity incentive plan (637) $ 1 (638)    
Issuance of common stock under equity incentive plan (in shares)   138      
Stock-based compensation expense 10,915   10,915    
Net loss (63,888)       (63,888)
Net unrealized loss on short-term investments (2)     (2)  
Comprehensive loss (63,890)        
Balance at Mar. 31, 2022 23,958 $ 1,021 1,700,264 (8) (1,677,319)
Balance (in shares) at Mar. 31, 2022   102,143      
Balance at Dec. 31, 2021 77,570 $ 1,020 1,689,987 (6) (1,613,431)
Balance (in shares) at Dec. 31, 2021   102,005      
Net loss (120,247)        
Net unrealized loss on short-term investments (5)        
Comprehensive loss (120,252)        
Balance at Jun. 30, 2022 (21,736) $ 1,025 1,710,928 (11) (1,733,678)
Balance (in shares) at Jun. 30, 2022   102,498      
Balance at Mar. 31, 2022 23,958 $ 1,021 1,700,264 (8) (1,677,319)
Balance (in shares) at Mar. 31, 2022   102,143      
Issuance of common stock under equity incentive plan (457) $ 2 (459)    
Issuance of common stock under equity incentive plan (in shares)   154      
Issuance of common stock on under the employee stock purchase plan 772 $ 2 770    
Issuance of common stock on under the employee stock purchase plan (in shares)   201      
Stock-based compensation expense 10,353   10,353    
Net loss (56,359)       (56,359)
Net unrealized loss on short-term investments (3)     (3)  
Comprehensive loss (56,362)        
Balance at Jun. 30, 2022 $ (21,736) $ 1,025 $ 1,710,928 $ (11) $ (1,733,678)
Balance (in shares) at Jun. 30, 2022   102,498