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Organization and Business - Additional Information (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2022 USD ($) Country	Dec. 31, 2021 USD ($)
Business [Line Items]
Accumulated deficit	$ (1,795,455)	$ (1,613,431)
Cash, cash equivalents and short-term investments	84,900
Net loss	$ (182,024)	$ (220,683)
H T X011 | European Countries and Canada
Business [Line Items]
Number of countries approved the drug | Country	31

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