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v3.23.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2023 | Mar. 31, 2022
Operating activities: |  |
Net loss | $ (32,768) | $ (63,888)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Stock-based compensation expense | 7,947 | 10,915
Depreciation and amortization | 718 | 721
Amortization of debt issuance costs | 51 | 50
(Accretion of discount) amortization of premium on short-term investments | (474) | 104
Impairment of property and equipment | 154 | 47
Loss on disposal of property and equipment |  | 96
Change in operating assets and liabilities: |  |
Accounts receivable | 601 | (5,604)
Inventory | 2,514 | (8,088)
Prepaid expenses and other assets | 906 | (405)
Accounts payable | 840 | 4,423
Accrued clinical and manufacturing liabilities | (3,195) | 13,561
Accrued payroll and employee liabilities | (3,906) | (3,049)
Other accrued and other non-current liabilities | 1,712 | 7,178
Net cash used in operating activities | (24,900) | (43,939)
Investing activities: |  |
Purchases of short-term investments | (13,942) | (38,023)
Maturities and sales of short-term investments | 51,000 | 49,957
Purchases of property and equipment | (224) | (1,044)
Proceeds from the sale of property and equipment |  | 56
Net cash provided by investing activities | 36,834 | 10,946
Financing activities: |  |
Payments for stock issued under the equity incentive plan | (208) | (637)
Net cash used in financing activities | (208) | (637)
Net increase (decrease) in cash and cash equivalents | 11,726 | (33,630)
Cash and cash equivalents at beginning of year | 15,364 | 90,541
Cash and cash equivalents at end of period | $ 27,090 | $ 56,911

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