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v3.23.1

Business - Additional Information (Details) $ in Thousands | 3 Months Ended |
--- | --- | ---
Mar. 31, 2023 USD ($) Country | Mar. 31, 2022 USD ($) | Dec. 31, 2022 USD ($)
Business [Line Items] |  |  |
Accumulated deficit | $ (1,828,223) |  | $ (1,795,455)
Cash, cash equivalents and short-term investments | 60,000 |  |
Net loss | $ 32,768 | $ 63,888 |
H T X011 | European Countries and Canada |  |  |
Business [Line Items] |  |  |
Number of countries approved the drug | Country | 31 |  |

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