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Business - Additional Information (Details) $ in Thousands	3 Months Ended
	Mar. 31, 2023 USD ($) Country	Mar. 31, 2022 USD ($)	Dec. 31, 2022 USD ($)
Business [Line Items]
Accumulated deficit	$ (1,828,223)		$ (1,795,455)
Cash, cash equivalents and short-term investments	60,000
Net loss	$ 32,768	$ 63,888
H T X011 | European Countries and Canada
Business [Line Items]
Number of countries approved the drug | Country	31

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