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Condensed Consolidated Statements of Stockholders' Equity (Deficit) (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
Total
Common Stock
Additional Paid-In Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Balance at Dec. 31, 2021 $ 77,570 $ 1,020 $ 1,689,987 $ (6) $ (1,613,431)
Balance (in shares) at Dec. 31, 2021   102,005      
Issuance of common stock under equity incentive plan (637) $ 1 (638)    
Issuance of common stock under equity incentive plan (in shares)   138      
Stock-based compensation expense 10,915   10,915    
Net loss (63,888)       (63,888)
Net unrealized gain (loss) on short-term investments (2)     (2)  
Comprehensive loss (63,890)        
Balance at Mar. 31, 2022 23,958 $ 1,021 1,700,264 (8) (1,677,319)
Balance (in shares) at Mar. 31, 2022   102,143      
Balance at Dec. 31, 2021 77,570 $ 1,020 1,689,987 (6) (1,613,431)
Balance (in shares) at Dec. 31, 2021   102,005      
Net loss (120,247)        
Net unrealized gain (loss) on short-term investments (5)        
Comprehensive loss (120,252)        
Balance at Jun. 30, 2022 (21,736) $ 1,025 1,710,928 (11) (1,733,678)
Balance (in shares) at Jun. 30, 2022   102,498      
Balance at Mar. 31, 2022 23,958 $ 1,021 1,700,264 (8) (1,677,319)
Balance (in shares) at Mar. 31, 2022   102,143      
Issuance of common stock under equity incentive plan (457) $ 2 (459)    
Issuance of common stock under equity incentive plan (in shares)   154      
Issuance of common stock under the employee stock purchase plan 772 $ 2 770    
Issuance of common stock on under the employee stock purchase plan (in shares)   201      
Stock-based compensation expense 10,353   10,353    
Net loss (56,359)       (56,359)
Net unrealized gain (loss) on short-term investments (3)     (3)  
Comprehensive loss (56,362)        
Balance at Jun. 30, 2022 (21,736) $ 1,025 1,710,928 (11) (1,733,678)
Balance (in shares) at Jun. 30, 2022   102,498      
Balance at Dec. 31, 2022 13,572 $ 1,191 1,807,855 (19) (1,795,455)
Balance (in shares) at Dec. 31, 2022   119,155      
Issuance of common stock under equity incentive plan (208) $ 2 (210)    
Issuance of common stock under equity incentive plan (in shares)   125      
Stock-based compensation expense 7,947   7,947    
Net loss (32,768)       (32,768)
Net unrealized gain (loss) on short-term investments 28     28  
Comprehensive loss (32,740)        
Balance at Mar. 31, 2023 (11,429) $ 1,193 1,815,592 9 (1,828,223)
Balance (in shares) at Mar. 31, 2023   119,280      
Balance at Dec. 31, 2022 13,572 $ 1,191 1,807,855 (19) (1,795,455)
Balance (in shares) at Dec. 31, 2022   119,155      
Net loss (74,827)        
Net unrealized gain (loss) on short-term investments 13        
Comprehensive loss (74,814)        
Balance at Jun. 30, 2023 (39,284) $ 1,199 1,829,805 (6) (1,870,282)
Balance (in shares) at Jun. 30, 2023   119,956      
Balance at Mar. 31, 2023 (11,429) $ 1,193 1,815,592 9 (1,828,223)
Balance (in shares) at Mar. 31, 2023   119,280      
Issuance of common stock under equity incentive plan (385) $ 3 (388)    
Issuance of common stock under equity incentive plan (in shares)   330      
Issuance of common stock under the employee stock purchase plan 704 $ 3 701    
Issuance of common stock on under the employee stock purchase plan (in shares)   346      
Stock-based compensation expense 13,900   13,900    
Net loss (42,059)       (42,059)
Net unrealized gain (loss) on short-term investments (15)     (15)  
Comprehensive loss (42,074)        
Balance at Jun. 30, 2023 $ (39,284) $ 1,199 $ 1,829,805 $ (6) $ (1,870,282)
Balance (in shares) at Jun. 30, 2023   119,956