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Condensed Consolidated Statements of Stockholders' Equity (Deficit) (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
Total
Private Placement
Common Stock
Common Stock
Private Placement
Additional Paid-In Capital
Additional Paid-In Capital
Private Placement
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Balance at Dec. 31, 2021 $ 77,570   $ 1,020   $ 1,689,987   $ (6) $ (1,613,431)
Balance (in shares) at Dec. 31, 2021     102,005          
Issuance of common stock under equity incentive plan (637)   $ 1   (638)      
Issuance of common stock under equity incentive plan (in shares)     138          
Stock-based compensation expense 10,915       10,915      
Net loss (63,888)             (63,888)
Net unrealized gains (losses) on short-term investments (2)           (2)  
Comprehensive loss (63,890)              
Balance at Mar. 31, 2022 23,958   $ 1,021   1,700,264   (8) (1,677,319)
Balance (in shares) at Mar. 31, 2022     102,143          
Balance at Dec. 31, 2021 77,570   $ 1,020   1,689,987   (6) (1,613,431)
Balance (in shares) at Dec. 31, 2021     102,005          
Net loss (162,155)              
Net unrealized gains (losses) on short-term investments (51)              
Comprehensive loss (162,206)              
Balance at Sep. 30, 2022 22,450   $ 1,188   1,796,905   (57) (1,775,586)
Balance (in shares) at Sep. 30, 2022     118,774          
Balance at Mar. 31, 2022 23,958   $ 1,021   1,700,264   (8) (1,677,319)
Balance (in shares) at Mar. 31, 2022     102,143          
Issuance of common stock under equity incentive plan (457)   $ 2   (459)      
Issuance of common stock under equity incentive plan (in shares)     154          
Issuance of common stock under the employee stock purchase plan 772   $ 2   770      
Issuance of common stock on under the employee stock purchase plan (in shares)     201          
Stock-based compensation expense 10,353       10,353      
Net loss (56,359)             (56,359)
Net unrealized gains (losses) on short-term investments (3)           (3)  
Comprehensive loss (56,362)              
Balance at Jun. 30, 2022 (21,736)   $ 1,025   1,710,928   (11) (1,733,678)
Balance (in shares) at Jun. 30, 2022     102,498          
Issuance of common stock under equity incentive plan (221)   $ 2   (223)      
Issuance of common stock under equity incentive plan (in shares)     147          
Issuance of common stock in a private placement, net   $ 75,163   $ 161   $ 75,002    
Issuance of common stock in a private placement, net (in shares)       16,129        
Stock-based compensation expense 11,198       11,198      
Net loss (41,908)             (41,908)
Net unrealized gains (losses) on short-term investments (46)           (46)  
Comprehensive loss (41,954)              
Balance at Sep. 30, 2022 22,450   $ 1,188   1,796,905   (57) (1,775,586)
Balance (in shares) at Sep. 30, 2022     118,774          
Balance at Dec. 31, 2022 13,572   $ 1,191   1,807,855   (19) (1,795,455)
Balance (in shares) at Dec. 31, 2022     119,155          
Issuance of common stock under equity incentive plan (208)   $ 2   (210)      
Issuance of common stock under equity incentive plan (in shares)     125          
Stock-based compensation expense 7,947       7,947      
Net loss (32,768)             (32,768)
Net unrealized gains (losses) on short-term investments 28           28  
Comprehensive loss (32,740)              
Balance at Mar. 31, 2023 (11,429)   $ 1,193   1,815,592   9 (1,828,223)
Balance (in shares) at Mar. 31, 2023     119,280          
Balance at Dec. 31, 2022 13,572   $ 1,191   1,807,855   (19) (1,795,455)
Balance (in shares) at Dec. 31, 2022     119,155          
Net loss (99,835)              
Net unrealized gains (losses) on short-term investments 18              
Comprehensive loss (99,817)              
Balance at Sep. 30, 2023 (27,786)   $ 1,411   1,866,094   (1) (1,895,290)
Balance (in shares) at Sep. 30, 2023     141,101          
Balance at Mar. 31, 2023 (11,429)   $ 1,193   1,815,592   9 (1,828,223)
Balance (in shares) at Mar. 31, 2023     119,280          
Issuance of common stock under equity incentive plan (385)   $ 3   (388)      
Issuance of common stock under equity incentive plan (in shares)     330          
Issuance of common stock under the employee stock purchase plan 704   $ 3   701      
Issuance of common stock on under the employee stock purchase plan (in shares)     346          
Stock-based compensation expense 13,900       13,900      
Net loss (42,059)             (42,059)
Net unrealized gains (losses) on short-term investments (15)           (15)  
Comprehensive loss (42,074)              
Balance at Jun. 30, 2023 (39,284)   $ 1,199   1,829,805   (6) (1,870,282)
Balance (in shares) at Jun. 30, 2023     119,956          
Issuance of common stock under equity incentive plan (308)   $ 4   (312)      
Issuance of common stock under equity incentive plan (in shares)     410          
Issuance of common stock in a private placement, net   $ 29,755   $ 208   $ 29,547    
Issuance of common stock in a private placement, net (in shares)       20,735        
Issuance of warrants in debt financing 371       371      
Stock-based compensation expense 6,683       6,683      
Net loss (25,008)             (25,008)
Net unrealized gains (losses) on short-term investments 5           5  
Comprehensive loss (25,003)              
Balance at Sep. 30, 2023 $ (27,786)   $ 1,411   $ 1,866,094   $ (1) $ (1,895,290)
Balance (in shares) at Sep. 30, 2023     141,101