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Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($) shares in Thousands, $ in Thousands |  | 3 Months Ended | 9 Months Ended |  |
--- | --- | --- | --- | --- | ---
Jan. 04, 2019 | Sep. 30, 2019 | Sep. 30, 2018 | Sep. 30, 2019 | Sep. 30, 2018 | Jan. 01, 2019 | Dec. 31, 2018
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |
Cash and cash equivalents |  | $ 85,465 |  | $ 85,465 |  |  | $ 88,438
Fair value of plan assets |  | 4,280 |  | 4,280 |  |  | 3,884
Accumulated depreciation of property and equipment |  | 45,533 |  | 45,533 |  |  | 42,797
Accumulated amortization of intangible assets |  | 22,410 |  | 22,410 |  |  | 20,105
Intangible Assets, Net |  | 11,577 |  | 11,577 |  |  | 5,137
Amount of goodwill at period end |  | 28,935 |  | 28,935 |  |  | 18,521
Increase in goodwill associated with foreign currency translation |  |  |  | 420 |  |  |
Right-of-use assets |  |  |  |  |  | $ 4,027 |
Lease liabilities |  |  |  |  |  | $ 4,263 |
Net foreign exchange gains (losses) |  | 50 | $ (375) | (875) | $ (30) |  |
Accumulated foreign currency adjustments included in other comprehensive loss amounted |  | 14,638 |  | 14,638 |  |  | 17,789
Unrealized loss on marketable securities |  | $ 40 |  | $ 40 |  |  | 917
Common Stock Options Unvested Restricted Stock and Unvested Performance Stock Units [Member] |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |
Number of anti-dilutive securities excluded from EPS computation |  | 909 | 304 | 709 | 256 |  |
Corebiome Inc. and Novosanis NV [Member] |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |
Intangible Assets, Accumulated Amortization |  |  |  | $ 1,831 |  |  |
Intangible Assets, acquired | $ 8,400 |  |  |  |  |  |
Intangible Assets, Foreign currency translation loss |  |  |  | 129 |  |  |
Amount of goodwill at period end | $ 9,994 |  |  |  |  |  |
Goodwill, acquired during period |  |  |  | $ 9,994 |  |  |
Minimum [Member] |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |
Useful life of Intangible assets |  |  |  | 5 years |  |  |
Minimum [Member] | Buildings [Member] |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |
Estimated useful lives of assets |  |  |  | 20 years |  |  |
Minimum [Member] | Computer Equipment [Member] |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |
Estimated useful lives of assets |  |  |  | 2 years |  |  |
Minimum [Member] | Machinery and Equipment [Member] |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |
Estimated useful lives of assets |  |  |  | 2 years |  |  |
Minimum [Member] | Furniture and Fixtures [Member] |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |
Estimated useful lives of assets |  |  |  | 2 years |  |  |
Maximum [Member] |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |
Useful life of Intangible assets |  |  |  | 15 years |  |  |
Maximum [Member] | Buildings [Member] |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |
Estimated useful lives of assets |  |  |  | 40 years |  |  |
Maximum [Member] | Computer Equipment [Member] |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |
Estimated useful lives of assets |  |  |  | 10 years |  |  |
Maximum [Member] | Machinery and Equipment [Member] |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |
Estimated useful lives of assets |  |  |  | 10 years |  |  |
Maximum [Member] | Furniture and Fixtures [Member] |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |
Estimated useful lives of assets |  |  |  | 10 years |  |  |
Money Market Fund [Member] | Level I Instruments [Member] |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |
Cash and cash equivalents |  | $ 18,790 |  | $ 18,790 |  |  | $ 21,631

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