<SEC-DOCUMENT>0001104659-26-077891-index.html : 20260626
<SEC-HEADER>0001104659-26-077891.hdr.sgml : 20260626
<ACCEPTANCE-DATETIME>20260625201217
ACCESSION NUMBER:		0001104659-26-077891
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		5
FILED AS OF DATE:		20260626
DATE AS OF CHANGE:		20260625

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ProQR Therapeutics N.V.
		CENTRAL INDEX KEY:			0001612940
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			P7
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-282419
		FILM NUMBER:		261123558

	BUSINESS ADDRESS:	
		ADDRESS IS A NON US LOCATION: 	YES
		STREET 1:		ZERNIKEDREEF 9
		CITY:			LEIDEN
		PROVINCE COUNTRY:   	P7
		BUSINESS PHONE:		31 88 166 7000

	MAIL ADDRESS:	
		ADDRESS IS A NON US LOCATION: 	YES
		STREET 1:		ZERNIKEDREEF 9
		CITY:			LEIDEN
		PROVINCE COUNTRY:   	P7

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ProQR Therapeutics B.V.
		DATE OF NAME CHANGE:	20140708
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>tm2618444-1_424b5.htm
<DESCRIPTION>424B5
<TEXT>
Document 1 - file: tm2618444-1_424b5.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>fc_natural-4clr.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: fc_natural-4clr.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>fc_programs-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: fc_programs-4c.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>fc_proqrpipline-4clr.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: fc_proqrpipline-4clr.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>lg_proqr-4c.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: lg_proqr-4c.jpg

</DOCUMENT>
</SEC-DOCUMENT>