<SEC-DOCUMENT>0001097241-15-000004.txt : 20150213
<SEC-HEADER>0001097241-15-000004.hdr.sgml : 20150213
<ACCEPTANCE-DATETIME>20150213104226
ACCESSION NUMBER:		0001097241-15-000004
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20150213
DATE AS OF CHANGE:		20150213

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IRONWOOD PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0001446847
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				043404176
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-85292
		FILM NUMBER:		15610716

	BUSINESS ADDRESS:	
		STREET 1:		301 BINNEY STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142
		BUSINESS PHONE:		617-621-7722

	MAIL ADDRESS:	
		STREET 1:		301 BINNEY STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			STATE OF WISCONSIN INVESTMENT BOARD
		CENTRAL INDEX KEY:			0000854157
		STANDARD INDUSTRIAL CLASSIFICATION:	UNKNOWN SIC - 0000 [0000]
		IRS NUMBER:				396006423
		STATE OF INCORPORATION:			WI
		FISCAL YEAR END:			0630

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		121 EAST WILSON STREET
		CITY:			MADISON
		STATE:			WI
		ZIP:			53703
		BUSINESS PHONE:		6082662381

	MAIL ADDRESS:	
		STREET 1:		P.O. BOX 7842
		STREET 2:		121 EAST WILSON STREET
		CITY:			MADISON
		STATE:			WI
		ZIP:			53707
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>ironwoodpharm201412swib.txt
<TEXT>
<PAGE>	1
                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C.  20549

                                  SCHEDULE 13G/A

                   UNDER THE SECURITIES EXCHANGE ACT OF 1934

                          (AMENDMENT NO.  ____1_____)*


	                  Ironwood Pharmaceuticals Inc
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
                               (Name of Issuer)

                               Common Class A
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
                        (Title of Class of Securities)


                                  46333X108
                           - - - - - - - - - - - - -
                                (CUSIP Number)


*The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class
of securities, and for any subsequent amendment containing information
which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities
Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of
that section of the Act but shall be subject to all other provisions of
the Act (however, see the Notes).

<PAGE>   2

Cusip No.     46333X108
	      - - - - - - -

                                      13G/A
____________________________________________________________________________
1. NAME OF REPORTING PERSON
   S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

		State of Wisconsin Investment Board
		      39-6006423
____________________________________________________________________________
2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP  *
								(a)____
                   Not Applicable				(b)____
____________________________________________________________________________
3. SEC USE ONLY

____________________________________________________________________________
4. CITZENSHIP OR PLACE OF ORGANIZATION
      Madison, Wisconsin
____________________________________________________________________________
NUMBERS OF 		5. SOLE VOTING POWER
SHARES				        3,728,485
BENEFICIALLY  	      _______________________________________________________
OWNED BY 		6. SHARED VOTING POWER
EACH 				        Not Applicable
REPORTING	      _______________________________________________________
PERSON 		        7. SOLE DISPOSITIVE POWER
WITH				        3,725,485
                      _________________ ______________________________________
		        8. SHARED DISPOSITIVE POWER
					Not Applicable
____________________________________________________________________________
9. 	AGGREGATE AMOUNT BENEFICALLY OWNED BY EACH REPORTING PERSON
                                        3,728,485
____________________________________________________________________________
10.	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
	SHARES *		        Not Applicable
____________________________________________________________________________
11. 	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
					3.014%
____________________________________________________________________________
12. 	TYPE OF REPORTING PERSON *

		EP (Public Pension Fund)
____________________________________________________________________________

                     *  SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>	3

ITEM 1.	ISSUER
        (a)  Ironwood Pharmaceuticals Inc
        (b)  301 Binney Street
             Cambridge, MA  02142

ITEM 2.	PERSON FILING
        (a) State of Wisconsin Investment Board
        (b) 121 East Wilson Street
    	    Madison, WI 53703
        (c) Wisconsin State Agency
        (d) See cover page
        (e) See cover page

ITEM 3.	THIS STATEMENT IS FILED PURSUANT TO 13d-1(b) or 13d-2(b) AND THE
        STATE OF WISCONSIN INVESTMENT BOARD IS A GOVERNMENT AGENCY WHICH
        MANAGES PUBLIC PENSION FUNDS SUBJECT TO PROVISIONS COMPARABLE TO
        ERISA.

ITEM 4.	OWNERSHIP
        (a) See Row 9 on Page 2
        (b) See Row 11 on Page 2
        (c) The State of Wisconsin Investment Board retains sole voting
            and dispositive power for all shares.

ITEM 5.	IF THIS STATEMENT IS BEING FILED TO REPORT THE FACT THAT AS OF THE
        DATE HEREOF THE REPORTING PERSON HAS CEASED TO BE THE BENEFICIAL
        OWNER OF MORE THAN FIVE PERCENT OF THE CLASS OF SECURITIES, CHECK
        THE FOLLOWING _____.

ITEM 6.	NOT APPLICABLE

ITEM 7.	NOT APPLICABLE

ITEM 8.	NOT APPLICABLE

ITEM 9.	NOT APPLICABLE

ITEM 10. CERTIFICATION

	By signing below I certify that, to the best of my knowledge and
belief, the securities referred to above were acquired in the ordinary
course of business and were not acquired for the purpose of and do not
have the effect of changing or influencing the control of the issuer of
such securities and were not acquired in connection with or as a
participant in any transaction having such purpose or effect.

                                   SIGNATURE

	After reasonable inquiry to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete
and correct.

                                February 12, 2015
                               - - - - - - - - - -
                                      Date

                                /s/ David Villa
                               - - - - - - - - -
                                   Signature

            David Villa, Chief Investment Officer - Investment Groups
            - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
                                   Name/Title



</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
