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Segment Reporting (Tables) | 9 Months Ended
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Sep. 30, 2025
Segment Reporting [Abstract] |
Summary of net loss reconciliation | The following table shows a reconciliation of the Company’s net loss, including the significant expense categories regularly provided to and reviewed by the CODM, as computed under U.S. GAAP, to the Company’s total net loss in the statements of operations and comprehensive loss, for the three and nine months ended September 30, 2025, and 2024 (in thousands): ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Three Months Ended September 30, | ​ | Nine Months Ended September 30,
​ |  | 2025 |  | 2024 | ​ | 2025 |  | 2024
Denifanstat external research and development expenses | ​ | ​ | 5,784 | ​ | ​ | 11,888 | ​ |  | 23,878 | ​ |  | 21,167
TVB-3567 external research and development expenses | ​ | ​ | 2,735 | ​ | ​ | 208 | ​ |  | 4,955 | ​ |  | 223
External general and administrative expenses | ​ |  | 2,315 | ​ |  | 1,971 | ​ | ​ | 6,946 | ​ | ​ | 6,313
Personnel costs | ​ | ​ | 1,733 | ​ | ​ | 1,707 | ​ | ​ | 5,459 | ​ | ​ | 4,701
Stock-based compensation | ​ | ​ | 1,688 | ​ | ​ | 1,546 | ​ |  | 4,758 | ​ |  | 3,754
Other segment items (1) | ​ |  | (1,347) | ​ |  | (2,701) | ​ | ​ | (4,526) | ​ | ​ | (6,792)
Segment net loss | ​ | $ | 12,908 | ​ | $ | 14,619 | ​ | $ | 41,470 | ​ | $ | 29,366
| (1) | Other segment items consist of (i) interest and other income, net and (ii) other internal operating research and development expenses.

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- Definition Tabular disclosure of the reconciliation of profit (loss) from reportable segments to the consolidated income (loss) before income tax expense (benefit) and discontinued operations. Includes, but is not limited to, reconciliation after income tax if income tax is allocated to the reportable segment. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 31 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-31 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 30 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-30 + Details
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