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Segment Reporting | 9 Months Ended
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Sep. 30, 2025
Segment Reporting [Abstract] |
Segment Reporting |
8. | Segment Reporting
Operating segments are defined as components of an entity about which discrete financial information is evaluated regularly by the chief operating decision maker (CODM) in deciding how to allocate resources and assess performance. The Company operates and manages its business as one business segment, which is development and commercialization of therapeutics for the treatment of MASH, acne and other diseases where FASN plays a pathogenic role. Accordingly, the Company has one reportable segment. The Company has a single management team that reports to the Chief Executive Officer, the Company's CODM, who comprehensively manages the entire Company. The accounting policies of the segment are the same as those described in the summary of significant accounting policies. ​ When evaluating the Company’s financial performance, the CODM is regularly provided with more detailed expense information than what is included in the Company’s statements of operations and comprehensive loss. The CODM uses net loss, as reported in the statements of operations and comprehensive loss, in evaluating the performance of the segment. Decisions regarding resource allocation are made primarily during the annual budget planning process and reallocated as needed throughout the year. The measure of segment assets is reported on the balance sheets as total assets. ​ The following table shows a reconciliation of the Company’s net loss, including the significant expense categories regularly provided to and reviewed by the CODM, as computed under U.S. GAAP, to the Company’s total net loss in the statements of operations and comprehensive loss, for the three and nine months ended September 30, 2025, and 2024 (in thousands): ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Three Months Ended September 30, | ​ | Nine Months Ended September 30,
​ |  | 2025 |  | 2024 | ​ | 2025 |  | 2024
Denifanstat external research and development expenses | ​ | ​ | 5,784 | ​ | ​ | 11,888 | ​ |  | 23,878 | ​ |  | 21,167
TVB-3567 external research and development expenses | ​ | ​ | 2,735 | ​ | ​ | 208 | ​ |  | 4,955 | ​ |  | 223
External general and administrative expenses | ​ |  | 2,315 | ​ |  | 1,971 | ​ | ​ | 6,946 | ​ | ​ | 6,313
Personnel costs | ​ | ​ | 1,733 | ​ | ​ | 1,707 | ​ | ​ | 5,459 | ​ | ​ | 4,701
Stock-based compensation | ​ | ​ | 1,688 | ​ | ​ | 1,546 | ​ |  | 4,758 | ​ |  | 3,754
Other segment items (1) | ​ |  | (1,347) | ​ |  | (2,701) | ​ | ​ | (4,526) | ​ | ​ | (6,792)
Segment net loss | ​ | $ | 12,908 | ​ | $ | 14,619 | ​ | $ | 41,470 | ​ | $ | 29,366
| (1) | Other segment items consist of (i) interest and other income, net and (ii) other internal operating research and development expenses.

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- Definition The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 21 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-21 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name 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