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Income Taxes - Provision for Income Taxes Reconciliation to Statutory Federal Income Tax Rate (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Income Tax Disclosure [Abstract] |  |  |
Federal tax benefit, at statutory rate | $ (10,021) | $ (23,192) | $ (8,311)
State benefit, net of federal benefit | (148) | (1,285) | 27
Foreign tax rate difference | (358) | (140) | 476
Valuation allowance against future tax benefits | 6,029 | 26,410 | 9,168
Gain on sale of foreign subsidiaries | 3,008 | 0 | 0
Sub-part F income | 791 | 0 | 0
Loss on conversion of debt | 0 | 2,015 | 0
Research and development credits | (1,415) | (2,355) | (1,456)
Share-based compensation | (879) | (1,134) | 341
Non-deductible officers compensation | 1,449 | 0 | 0
True-up of prior year provisions | 1,681 | 0 | 0
Other | 54 | 429 | 291
Provision for income taxes | $ 191 | $ 748 | $ 536

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- Definition Amount of difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying domestic federal statutory income tax rate to pretax income (loss) from continuing operation, attributable to expense for award under share-based payment arrangement. Excludes expense determined to be nondeductible upon grant or after for award under share-based payment arrangement. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=121826272&loc=d3e32687-109319 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 740 -Section 35 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=120384911&loc=d3e23163-113944 + Details
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