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v3.23.1

Segment, Geographical and Other Revenue Information - Segment Reporting (Details) - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2023 | Mar. 31, 2022
Segment Reporting Information [Line Items] |  |
Total revenues | $ 12,982 | $ 35,340
Cost of product revenue | 4,521 | 8,521
Research and development | 16,655 | 19,500
Selling, general and administrative | 15,399 | 15,705
Restructuring charges | 72 | 0
Total costs and operating expenses | 36,647 | 43,726
Loss from operations | (23,665) | (8,386)
Unallocated depreciation and amortization | (1,466) | (1,215)
Stock-based compensation | 2,809 | 3,838
Performance Enzymes |  |
Segment Reporting Information [Line Items] |  |
Total revenues | 9,486 | 33,099
Novel Biotherapeutics |  |
Segment Reporting Information [Line Items] |  |
Total revenues | 3,496 | 2,241
Operating Segments |  |
Segment Reporting Information [Line Items] |  |
Total revenues | 12,982 | 35,340
Cost of product revenue | 4,521 | 8,521
Research and development | 15,411 | 18,468
Selling, general and administrative | 3,749 | 4,261
Restructuring charges | 72 | 0
Total costs and operating expenses | 23,753 | 31,250
Loss from operations | (10,771) | 4,090
Operating Segments | Performance Enzymes |  |
Segment Reporting Information [Line Items] |  |
Total revenues | 9,486 | 33,099
Cost of product revenue | 4,521 | 8,521
Research and development | 8,099 | 6,122
Selling, general and administrative | 2,798 | 3,541
Restructuring charges | 0 | 0
Total costs and operating expenses | 15,418 | 18,184
Loss from operations | (5,932) | 14,915
Stock-based compensation | 1,035 | 1,690
Operating Segments | Novel Biotherapeutics |  |
Segment Reporting Information [Line Items] |  |
Total revenues | 3,496 | 2,241
Cost of product revenue | 0 | 0
Research and development | 7,312 | 12,346
Selling, general and administrative | 951 | 720
Restructuring charges | 72 | 0
Total costs and operating expenses | 8,335 | 13,066
Loss from operations | (4,839) | (10,825)
Stock-based compensation | 413 | 410
Corporate |  |
Segment Reporting Information [Line Items] |  |
Total costs and operating expenses | (10,364) | (11,205)
Unallocated depreciation and amortization | (1,466) | (1,232)
Loss before income taxes | (22,601) | (8,347)
Stock-based compensation | 1,361 | 1,738
Product revenue |  |
Segment Reporting Information [Line Items] |  |
Total revenues | 8,364 | 30,690
Product revenue | Performance Enzymes |  |
Segment Reporting Information [Line Items] |  |
Total revenues | 8,364 | 30,690
Product revenue | Novel Biotherapeutics |  |
Segment Reporting Information [Line Items] |  |
Total revenues | 0 | 0
Product revenue | Operating Segments |  |
Segment Reporting Information [Line Items] |  |
Total revenues | 8,364 | 30,690
Product revenue | Operating Segments | Performance Enzymes |  |
Segment Reporting Information [Line Items] |  |
Total revenues | 8,364 | 30,690
Product revenue | Operating Segments | Novel Biotherapeutics |  |
Segment Reporting Information [Line Items] |  |
Total revenues | 0 | 0
Research and development revenue |  |
Segment Reporting Information [Line Items] |  |
Total revenues | 4,618 | 4,650
Research and development revenue | Performance Enzymes |  |
Segment Reporting Information [Line Items] |  |
Total revenues | 1,122 | 2,409
Research and development revenue | Novel Biotherapeutics |  |
Segment Reporting Information [Line Items] |  |
Total revenues | 3,496 | 2,241
Research and development revenue | Operating Segments |  |
Segment Reporting Information [Line Items] |  |
Total revenues | 4,618 | 4,650
Research and development revenue | Operating Segments | Performance Enzymes |  |
Segment Reporting Information [Line Items] |  |
Total revenues | 1,122 | 2,409
Research and development revenue | Operating Segments | Novel Biotherapeutics |  |
Segment Reporting Information [Line Items] |  |
Total revenues | $ 3,496 | $ 2,241

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