Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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Amount of write-down of assets recognized in the income statement. Includes, but is not limited to, losses from tangible assets, intangible assets and goodwill.

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Amount of assets held-for-sale that are not part of a disposal group.

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The amount of expense recognized in the current period that reflects the allocation of the cost of tangible assets over the assets' useful lives. Includes production and non-production related depreciation.

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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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Balance Sheets Details - Property and Equipment, net (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022	Dec. 31, 2022
Property, Plant and Equipment [Line Items]
Property and equipment	$ 54,369		$ 54,369		$ 62,435
Less: accumulated depreciation and amortization	(39,087)		(39,087)		(39,821)
Property and equipment, net	15,282		15,282		22,614
Asset, held-for-sale, not part of disposal group	600		600
Asset impairment charges	1,500
Depreciation	1,357	$ 1,405	4,302	$ 3,961
San Carlos
Property, Plant and Equipment [Line Items]
Impairment of leasehold	4,700		4,700
Asset impairment charges	7,700		7,700
Laboratory equipment
Property, Plant and Equipment [Line Items]
Property and equipment	36,376		36,376		39,679
Asset, held-for-sale, not part of disposal group	2,100		2,100
Leasehold improvements
Property, Plant and Equipment [Line Items]
Property and equipment	11,750		11,750		16,633
Computer equipment and software
Property, Plant and Equipment [Line Items]
Property and equipment	3,096		3,096		3,039
Office equipment and furniture
Property, Plant and Equipment [Line Items]
Property and equipment	1,366		1,366		1,345
Construction in progress
Property, Plant and Equipment [Line Items]
Property and equipment	$ 1,781		$ 1,781		$ 1,739