<SEC-DOCUMENT>0001567619-23-002895.txt : 20230214
<SEC-HEADER>0001567619-23-002895.hdr.sgml : 20230214
<ACCEPTANCE-DATETIME>20230214161158
ACCESSION NUMBER:		0001567619-23-002895
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20230210
FILED AS OF DATE:		20230214
DATE AS OF CHANGE:		20230214

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Ryali Sriram
		CENTRAL INDEX KEY:			0001762893

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-34705
		FILM NUMBER:		23629327

	MAIL ADDRESS:	
		STREET 1:		C/O EIGER BIOPHARMACEUTICALS, INC.
		STREET 2:		2155 PARK BLVD.
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94306

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CODEXIS, INC.
		CENTRAL INDEX KEY:			0001200375
		STANDARD INDUSTRIAL CLASSIFICATION:	INDUSTRIAL ORGANIC CHEMICALS [2860]
		IRS NUMBER:				710872999
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		200 PENOBSCOT DRIVE
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063
		BUSINESS PHONE:		650-421-8100

	MAIL ADDRESS:	
		STREET 1:		200 PENOBSCOT DRIVE
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CODEXIS INC
		DATE OF NAME CHANGE:	20021022
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc1.xml
<DESCRIPTION>FORM 4
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2023-02-10</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001200375</issuerCik>
        <issuerName>CODEXIS, INC.</issuerName>
        <issuerTradingSymbol>CDXS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001762893</rptOwnerCik>
            <rptOwnerName>Ryali Sriram</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CODEXIS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>200 PENOBSCOT DRIVE</rptOwnerStreet2>
            <rptOwnerCity>REDWOOD CITY</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94063</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Financial Officer</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2023-02-10</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>111791</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>111791</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>5.86</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2023-02-10</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>372637</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2033-02-10</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>372637</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>372637</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Restricted Stock. The shares vest as to one third of the shares on each yearly anniversary of the date of grant, provided that the Reporting Person provides continuous services to the Issuer as an employee, consultant, director or officer through each such vesting date.</footnote>
        <footnote id="F2">Option was granted pursuant to the Issuer's 2022 Employment Inducement Award Plan and vests and becomes exercisable with respect to 25% of the shares subject thereto on February 10, 2024, with 1/48th of the shares vesting monthly thereafter, such that the option will be fully vested and exercisable on February 10, 2027, in each case, subject to continued service through the applicable vesting date.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Margaret Nell Fitzgerald, as Attorney-in-Fact for Sriram Ryali</signatureName>
        <signatureDate>2023-02-14</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>poa_ryali.htm
<TEXT>
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  <head>
    <title></title>
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<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <div>
    <div style="text-align: center; margin-bottom: 12pt; font-family: 'Times New Roman', serif; font-size: 12pt; font-weight: bold;">POWER OF ATTORNEY</div>
    <div style="text-indent: 36pt; color: #000000; font-family: 'Times New Roman', serif; font-size: 10.5pt;">Know all by these presents, that the undersigned hereby constitutes and appoints each of (i) the President of Codexis, Inc., a
      Delaware corporation (the &#8220;<font style="font-weight: bold;">Company</font>&#8221;), who is currently Stephen Dilly, (ii) the Company's Chief Financial Officer, (iii) the Company&#8217;s Chief Legal
      Officer, who is currently Margaret Nell Fitzgerald, and (iv) the Company&#8217;s Senior Corporate Counsel, who is currently Richard A. Sabalot, and their respective successors, signing singly, with full power of substitution, as the undersigned's true and
      lawful attorney-in-fact to:</div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000; margin-top: 12pt;" class="DSPFListTable" id="z479fd210811b423f90256984b8715b55" cellpadding="0" cellspacing="0">

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          <td style="width: 36pt;"><br>
          </td>
          <td style="width: 36pt; vertical-align: top; color: #000000; font-family: 'Times New Roman', serif; font-size: 10.5pt;">(1)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 10.5pt;">execute for and on behalf of the undersigned, in the undersigned&#8217;s capacity as a director and/or officer of the Company, Forms&#160;3, 4 and 5 (including
              amendments thereto) in accordance with Section&#160;16(a) of the Securities Exchange Act of 1934 and the rules and regulations thereunder and a Form ID, Uniform Application for Access Codes to File on EDGAR;</div>
          </td>
        </tr>

    </table>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000; margin-top: 12pt;" class="DSPFListTable" id="zf2bb9128e8ae4184b31649b7ddf401f3" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 36pt;"><br>
          </td>
          <td style="width: 36pt; vertical-align: top; color: #000000; font-family: 'Times New Roman', serif; font-size: 10.5pt;">(2)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 10.5pt;">do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Forms 3, 4 or 5 or
              Form ID and timely file such forms (including amendments thereto) and application with the United States Securities and Exchange Commission and any stock exchange or similar authority; and</div>
          </td>
        </tr>

    </table>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000; margin-top: 12pt;" class="DSPFListTable" id="z5894343b0b514a949ae5bbaee80db58a" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 36pt;"><br>
          </td>
          <td style="width: 36pt; vertical-align: top; color: #000000; font-family: 'Times New Roman', serif; font-size: 10.5pt;">(3)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', serif; font-size: 10.5pt;">take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the
              best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such
              terms and conditions as such attorney-in-fact may approve in such attorney-in-fact's discretion.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-indent: 36pt; color: #000000; font-family: 'Times New Roman', serif; font-size: 10.5pt;">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and every act and
      thing whatsoever requisite, necessary or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of
      substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers
      herein granted.&#160; The undersigned acknowledges that the foregoing attorneys-in-fact, in serving in such capacity at the request of the undersigned, are not assuming, nor is the Company assuming, any of the undersigned's responsibilities to comply with
      Section&#160;16 of the Securities Exchange Act of 1934.</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; font-family: 'Times New Roman', serif; font-size: 10.5pt;">The undersigned agrees that each such attorney-in-fact herein may rely entirely on information furnished orally or in writing by the undersigned
      to such attorney-in-fact.&#160; The undersigned also agrees to indemnify and hold harmless the Company and each such attorney-in-fact against any losses, claims, damages or liabilities (or actions in these respects) that arise out of or are based upon any
      untrue statements or omission of necessary facts in the information provided by the undersigned to such attorney-in fact for purposes of executing, acknowledging, delivering or filing Forms 3, 4 or 5 (including amendments thereto) or Form ID and
      agrees to reimburse the Company and such attorney-in-fact for any legal or other expenses reasonably incurred in connection with investigating or defending against any such loss, claim, damage, liability or action.</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; color: #000000; font-family: 'Times New Roman', serif; font-size: 10.5pt;">This Power of Attorney supersedes any power of attorney previously executed by the undersigned regarding the purposes outlined
      in the first paragraph hereof (&#8220;<font style="font-weight: bold; font-style: italic;">Prior Powers of Attorney</font>&#8221;), and the authority of the attorneys-in-fact named in any Prior Powers of
      Attorney is hereby revoked.</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; font-family: 'Times New Roman', serif; font-size: 10.5pt;">This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file Forms&#160;3, 4 or 5 with respect to
      the undersigned's holdings of and transactions in securities issued by the Company, unless earlier (a)&#160;revoked by the undersigned in a signed writing delivered to the foregoing attorneys-in-fact or (b)&#160;superseded by a new power of attorney regarding
      the purposes outlined in the first paragraph hereof dated as of a later date.</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; color: #000000; font-family: 'Times New Roman', serif; font-size: 10.5pt;">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this 25<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> day of January,
      2023.</div>
    <div><br>
    </div>
    <div style="margin-left: 279pt; margin-top: 12pt;"><font style="font-family: 'Times New Roman', serif; font-size: 10.5pt;"><u>/s/ Sri Ryali</u></font><font style="display: inline-block; text-indent: 0px; font-size: 1px; width: 153pt" class="TRGRRTFtoHTMLTab">&#160;</font></div>
    <div style="margin-left: 279pt; font-family: 'Times New Roman', serif; font-size: 10.5pt; font-weight: bold;">Sri Ryali</div>
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