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Collaborative Arrangements - Merck Sitagliptin Catalyst Supply Agreement (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Dec. 31, 2015 | Feb. 29, 2012 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Performance obligations satisfied |  |  | $ 17,937 | $ 2,038 |  |  |
Revenues |  |  |  |  | $ 70,143 | $ 138,590 | $ 104,754
Product revenue |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Revenues |  |  |  |  | $ 42,906 | $ 116,676 | $ 70,657
Sitagliptin Enzyme | Revenue Benchmark | Collaborative Arrangement Concentration Risk |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Concentration risk, percentage |  |  |  |  | 6.00% | 4.00% | 9.00%
Merck | Sitagliptin Enzyme |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Revenues |  |  |  |  | $ 700 |  |
Merck | Supply Agreement |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Term of collaborative research and development agreement | 5 years | 5 years |  |  |  |  |
Merck | Supply Agreement | Product revenue |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Performance obligations satisfied |  |  |  |  | $ 4,400 | $ 5,900 | $ 9,800

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