<SEC-DOCUMENT>0001535264-25-000054.txt : 20250814
<SEC-HEADER>0001535264-25-000054.hdr.sgml : 20250814
<ACCEPTANCE-DATETIME>20250814163453
ACCESSION NUMBER:		0001535264-25-000054
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250814
DATE AS OF CHANGE:		20250814

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			InfuSystem Holdings, Inc
		CENTRAL INDEX KEY:			0001337013
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				203341405
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-81749
		FILM NUMBER:		251220105

	BUSINESS ADDRESS:	
		STREET 1:		3851 WEST HAMLIN ROAD
		CITY:			ROCHESTER HILLS
		STATE:			MI
		ZIP:			48309
		BUSINESS PHONE:		(248) 291-1210

	MAIL ADDRESS:	
		STREET 1:		3851 WEST HAMLIN ROAD
		CITY:			ROCHESTER HILLS
		STATE:			MI
		ZIP:			48309

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	HAPC, Inc.
		DATE OF NAME CHANGE:	20060425

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Healthcare Acquisition Partners Corp.
		DATE OF NAME CHANGE:	20050824

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AWM Investment Company, Inc.
		CENTRAL INDEX KEY:			0001535264
		ORGANIZATION NAME:           	
		EIN:				113086452
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		527 MADISON AVENUE
		STREET 2:		SUITE 2600
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		212-319-6670

	MAIL ADDRESS:	
		STREET 1:		527 MADISON AVENUE
		STREET 2:		SUITE 2600
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001535264</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>10</amendmentNo>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>06/30/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001337013</issuerCik>
        <issuerName>InfuSystem Holdings, Inc</issuerName>
        <issuerCusip>45685K102</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>3851 WEST HAMLIN ROAD</com:street1>
          <com:city>ROCHESTER HILLS</com:city>
          <com:stateOrCountry>MI</com:stateOrCountry>
          <com:zipCode>48309</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>AWM Investment Company, Inc.</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>1272296.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>1272296.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1272296.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>6.1</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
      <comments>AWM Investment Company, Inc., a Delaware corporation (AWM), is the investment adviser to Special Situations Life Sciences Fund, L.P. (SSLS) (SSLS will hereafter be referred to as the Fund).  As the investment adviser to the Fund, AWM holds sole voting and investment power over 1,272,296 Shares held by SSLS.
</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>InfuSystem Holdings, Inc</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>3851 WEST HAMLIN ROAD, ROCHESTER HILLS, MICHIGAN, 48309</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>The person filing this report is AWM Investment Company, Inc., a Delaware corporation (AWM), which is the investment adviser to Special Situations Life Sciences Fund, L.P. a Delaware limited partnership (SSLS), (SSLS, will hereafter be referred to as the Fund).  The principal business of the Fund is to invest in equity and equity-related securities and other securities of any kind or nature.

David M. Greenhouse (Greenhouse) and Adam C. Stettner (Stettner) are members of LS Advisers, L.LC., a New York limited liability company (LS). Greenhouse and Stettner are also controlling principals of AWM.
</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>The principal business address for AWM is c/o Special Situations Funds, 527 Madison Avenue, Suite 2600, New York, NY  10022.</principalBusinessOfficeOrResidenceAddress>
        <citizenship>AWM is a Delaware Corporation</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>1,272,296</amountBeneficiallyOwned>
        <classPercent>6.1</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>AWM is the investment adviser to the Fund. As the investment adviser to the Fund, AWM holds sole voting power over 1,272,296 shares of Common Stock of the Issuer (the Shares) held by SSLS. Greenhouse and Stettner are members of LS, the general partner of SSLS. Greenhouse and Stettner are also controlling principals of AWM.</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>AWM is the investment adviser to the Fund. As the investment adviser to the Fund, AWM holds sole investment power over 1,272,296 shares of Common Stock of the Issuer (the Shares) held by SSLS. Greenhouse and Stettner are members of LS, the general partner of SSLS. Greenhouse and Stettner are also controlling principals of AWM.</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>0</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under &amp;#167; 240.14a-11.

</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>AWM Investment Company, Inc.</reportingPersonName>
      <signatureDetails>
        <signature>Adam Stettner</signature>
        <title>Executive Vice President</title>
        <date>08/14/2025</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
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</SEC-DOCUMENT>
