EXHIBIT 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
RXi Pharmaceuticals Corporation
Worcester, MA
We hereby consent to the incorporation by reference in the Registration Statements on Form S-8
(Nos. 333-151154 and 333-1583847) of RXi Pharmaceuticals Corporation of our report dated March 13,
2009, relating to the financial statements which appear in this Form 10-K.
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| /s/ BDO Seidman, LLP
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| Boston, MA |
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March 13. 2009