<SUBMISSION>
<ACCESSION-NUMBER>0001209191-09-019006
<TYPE>3
<PUBLIC-DOCUMENT-COUNT>1
<PERIOD>20090327
<FILING-DATE>20090331
<DATE-OF-FILING-DATE-CHANGE>20090331
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>Varanasi Ramani
<CIK>0001460224
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>3
<ACT>34
<FILE-NUMBER>001-33958
<FILM-NUMBER>09720622
</FILING-VALUES>
<MAIL-ADDRESS>
<STREET1>342 BUNKER HILL ST. #5D
<CITY>CHARLESTOWN
<STATE>MA
<ZIP>02129
</MAIL-ADDRESS>
</REPORTING-OWNER>
<ISSUER>
<COMPANY-DATA>
<CONFORMED-NAME>RXI PHARMACEUTICALS CORP
<CIK>0001390478
<ASSIGNED-SIC>2834
<IRS-NUMBER>000000000
</COMPANY-DATA>
<BUSINESS-ADDRESS>
<STREET1>60 PRESCOTT  STREET
<CITY>WORCESTER
<STATE>MA
<ZIP>01605
<PHONE>508-767-3861
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>60 PRESCOTT  STREET
<CITY>WORCESTER
<STATE>MA
<ZIP>01605
</MAIL-ADDRESS>
</ISSUER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>doc3.xml
<DESCRIPTION>FORM 3 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2009-03-27</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001390478</issuerCik>
        <issuerName>RXI PHARMACEUTICALS CORP</issuerName>
        <issuerTradingSymbol>RXII</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001460224</rptOwnerCik>
            <rptOwnerName>Varanasi Ramani</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O RXI PHARMACEUTICALS CORPORATION</rptOwnerStreet1>
            <rptOwnerStreet2>60 PRESCOTT STREET</rptOwnerStreet2>
            <rptOwnerCity>WORCESTER</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>01605</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>VP, Business Development</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <footnotes></footnotes>

    <remarks>No securities beneficially owned.</remarks>

    <ownerSignature>
        <signatureName>/s/ Ramani Varanasi</signatureName>
        <signatureDate>2009-03-31</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SUBMISSION>
