<SUBMISSION>
<ACCESSION-NUMBER>0000950135-09-000101
<TYPE>8-K
<PUBLIC-DOCUMENT-COUNT>2
<PERIOD>20090101
<ITEMS>5.02
<ITEMS>9.01
<FILING-DATE>20090107
<DATE-OF-FILING-DATE-CHANGE>20090107
<FILER>
<COMPANY-DATA>
<CONFORMED-NAME>RXI PHARMACEUTICALS CORP
<CIK>0001390478
<ASSIGNED-SIC>2834
<IRS-NUMBER>000000000
</COMPANY-DATA>
<FILING-VALUES>
<FORM-TYPE>8-K
<ACT>34
<FILE-NUMBER>001-33958
<FILM-NUMBER>09513622
</FILING-VALUES>
<BUSINESS-ADDRESS>
<STREET1>60 PRESCOTT  STREET
<CITY>WORCESTER
<STATE>MA
<ZIP>01605
<PHONE>508-767-3861
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>60 PRESCOTT  STREET
<CITY>WORCESTER
<STATE>MA
<ZIP>01605
</MAIL-ADDRESS>
</FILER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>b73549rxe8vk.htm
<DESCRIPTION>RXI PHARMACEUTICALS CORPORATION
<TEXT>
<HTML>
<HEAD>
<TITLE>e8vk</TITLE>
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<BODY bgcolor="#FFFFFF">
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<H5 align="left" style="page-break-before:always"><A HREF="#toc">Table of Contents</A></H5><P>
<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>
<DIV style="width: 100%; border-bottom: 1pt solid black; font-size: 1pt">&nbsp;</DIV>




<DIV align="center" style="font-size: 14pt; margin-top: 12pt"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION</B>
</DIV>

<DIV align="center" style="font-size: 12pt"><B>WASHINGTON, D.C. 20549</B>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 12pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 16pt; width: 26%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>

<DIV align="center" style="font-size: 18pt; margin-top: 12pt"><B>FORM 8-K</B>
</DIV>


<DIV align="center" style="font-size: 12pt; margin-top: 12pt"><B>CURRENT REPORT<BR>
PURSUANT TO SECTION 13 OR 15(D) OF THE<BR>
THE SECURITIES EXCHANGE ACT OF 1934</B>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 12pt"><B>Date of report (Date of earliest event reported): January&nbsp;1, 2009</B></DIV>

<DIV align="center" style="font-size: 24pt; margin-top: 12pt"><B><FONT style="border-bottom: 1px solid #000000">RXI PHARMACEUTICALS CORPORATION</FONT></B>
</DIV>

<DIV align="center" style="font-size: 10pt">(Exact name of registrant as specified in its charter)</DIV>


<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
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<TR valign="bottom">
    <TD width="30%">&nbsp;</TD>
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    <TD width="30%">&nbsp;</TD>
</TR>
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<TR valign="bottom">
    <TD align="center" valign="top">Delaware
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">001-33958
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">20-8099512</TD>
</TR>
<TR style="font-size: 1px">
    <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">(State or other jurisdiction
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">(Commission
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">(I.R.S. Employer</TD>
</TR>
<TR valign="bottom">
    <TD align="center" valign="top">of incorporation or organization)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">File Number)
</TD>
    <TD>&nbsp;</TD>
    <TD align="center" valign="top">Identification No.)</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 12pt">60 Prescott Street, Worcester, MA 01605</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 0pt"><DIV align="center"><DIV style="font-size: 3pt; margin-top: 0pt; width: 36%; border-top: 1px solid #000000">&nbsp;</DIV></DIV></DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 0pt">(Address of Principal Executive Offices) (Zip Code)</DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 12pt">Registrant&#146;s telephone number, including area code: (508)&nbsp;767-3861</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions (<I>see </I>General Instruction A.2. below):
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="left"><FONT face="Wingdings">&#111;</FONT></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Written communications pursuant to Rule&nbsp;425 under the Securities Act
(17 CFR 230.425)</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="left"><FONT face="Wingdings">&#111;</FONT></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Soliciting material pursuant to Rule&nbsp;14a-12 under the Exchange Act
(17 CFR 240.14a-12)</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="left"><FONT face="Wingdings">&#111;</FONT></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Pre-commencement communications pursuant to Rule&nbsp;14d-2(b) under the Exchange Act
(17 CFR 240.14d-2(b))</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="left"><FONT face="Wingdings">&#111;</FONT></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Pre-commencement communications pursuant to Rule&nbsp;13e-4(c) under the Exchange Act
(17 CFR 240.13e-4(c))</TD>
</TR>

</TABLE>
</DIV>

<DIV style="width: 100%; border-bottom: 1pt solid black; margin-top: 10pt; font-size: 1pt">&nbsp;</DIV>
<DIV style="width: 100%; border-bottom: 2pt solid black; font-size: 1pt">&nbsp;</DIV>





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<!-- TOC -->
<A name="toc"><DIV align="CENTER" style="page-break-before:always"><U><B>TABLE OF CONTENTS</B></U></DIV></A>

<P><CENTER>
<TABLE border="0" width="90%" cellpadding="0" cellspacing="0">
<TR>
	<TD width="3%"></TD>
	<TD width="3%"></TD>
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</TR>
<TR><TD colspan="9"><A HREF="#000">Item&nbsp;5.02 Departure of Directors or Principal Officers; Election of&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Directors; Appointment of Principal Officers; Compensatory Arrangements of Certain Officers</A></TD></TR>
<TR><TD colspan="9"><A HREF="#001">Item&nbsp;9.01 Financial Statements and Exhibits</A></TD></TR>
<TR><TD colspan="9"><A HREF="#002">Signature</A></TD></TR>
<TR><TD colspan="9"><A HREF="#003">Index to Exhibits</A></TD></TR>
<TR><TD colspan="9"><A HREF="b73549rxexv10w1.htm">EX-10.1 - Employment Agreement effective as of January 1, 2009 between RXi Pharmaceuticals Corporation and Tod Woolf</A></TD></TR>
</TABLE>
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<!-- link1 "Item&nbsp;5.02 Departure of Directors or Principal Officers; Election of&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Directors; Appointment of Principal Officers; Compensatory Arrangements of Certain Officers" -->
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    <TD></TD>
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    <TD nowrap align="left"><B>Item&nbsp;5.02</B></TD>
    <TD>&nbsp;</TD>
    <TD><B>Departure of Directors or Principal Officers; Election of
Directors; Appointment of Principal
Officers; Compensatory Arrangements of Certain Officers.</B></TD>
</TR>
</TABLE>
</DIV>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">(e)&nbsp;On January&nbsp;1, 2009, RXi Pharmaceuticals Corporation (the &#147;Company&#148;) entered into an employment
agreement (the &#147;Agreement&#148;) with Tod Woolf, who will continue to serve as the Company&#146;s President
and Chief Executive Officer. Dr.&nbsp;Woolf&#146;s prior employment agreement with the Company expired on
December&nbsp;31, 2008. Under the Agreement, Dr.&nbsp;Woolf is entitled to an annual base salary of $375,000
and may be eligible for an annual bonus and grants of stock options as determined by the Company in
its sole discretion. The Agreement expires on December&nbsp;31, 2009, but may be terminated by the
Company or Dr.&nbsp;Woolf at any time. If the Company terminates Dr.&nbsp;Woolf&#146;s employment without cause
(as defined in the Agreement), or if Dr.&nbsp;Woolf terminates his employment for good reason (as
defined in the Agreement), Dr.&nbsp;Woolf will be entitled to the salary and any stock options that
would otherwise have been payable or would otherwise have vested for the period of time which is
equal to the earlier of either (i)&nbsp;the twelve-month anniversary of his termination date or (ii)&nbsp;the
remainder of the term of the Agreement, but in no event less than 6&nbsp;months.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The above description is not complete and is qualified in its entirety by reference to the
Agreement, a copy of which are filed with this report as Exhibit&nbsp;10.1.
</DIV>
<!-- link1 "Item&nbsp;9.01 Financial Statements and Exhibits" -->
<DIV align="left"><A NAME="001"></A></DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Item&nbsp;9.01 Financial Statements and Exhibits.</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">(d)&nbsp;Exhibits

</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left">10.1</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Employment Agreement effective as of January&nbsp;1, 2009 between
RXi Pharmaceuticals Corporation and Tod Woolf.</TD>
</TR>

</TABLE>
</DIV>
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<DIV style="font-family: 'Times New Roman',Times,serif">


<DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">



</TABLE>
</DIV>
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<DIV align="left"><A NAME="002"></A></DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Signature</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly
caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
</DIV>
<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
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<TR valign="bottom">
    <TD width="45%">&nbsp;</TD>
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    <TD width="2%">&nbsp;</TD>
    <TD width="45%">&nbsp;</TD>
</TR>
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<TR valign="bottom">
    <TD valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="3" valign="top" align="left">RXI PHARMACEUTICALS CORPORATION</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Date: January&nbsp;7, 2009
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">By:
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">/s/ Stephen J. DiPalma</TD>
</TR>
<TR style="font-size: 1px">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Name:
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Stephen J. DiPalma</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Title:
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Chief Financial Officer</TD>
</TR>
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</TABLE>
</DIV>


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<DIV style="font-family: 'Times New Roman',Times,serif">

<!-- link1 "Index to Exhibits" -->
<DIV align="left"><A NAME="003"></A></DIV>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><B>Index to Exhibits</B>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="left">10.1</TD>
    <TD width="1%">&nbsp;</TD>
    <TD>Employment Agreement effective as of January&nbsp;1, 2009 between RXi
Pharmaceuticals Corporation and Tod Woolf.</TD>
</TR>

</TABLE>
</DIV>


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<DOCUMENT>
<TYPE>EX-10.1
<SEQUENCE>2
<FILENAME>b73549rxexv10w1.htm
<DESCRIPTION>EX-10.1 - EMPLOYMENT AGREEMENT EFFECTIVE AS OF JANUARY 1, 2009 BETWEEN RXI PHARMACEUTICALS CORPORATION AND TOD WOOLF
<TEXT>
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<DIV align="right" style="font-size: 10pt; margin-top: 12pt"><B>Exhibit&nbsp;10.1</B>
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><U><B>EMPLOYMENT AGREEMENT</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Employment Agreement (this &#147;Agreement&#148;) is made and entered into as of January&nbsp;1, 2009
(&#147;Effective Date&#148;) by and between RXi Pharmaceuticals Corporation (&#147;Employer&#148;), a Delaware
corporation, and Tod Woolf, an individual and resident of the Commonwealth of Massachusetts
(&#147;Employee&#148;).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;WHEREAS, Employer and Employee desire to enter into an employment agreement under which
Employee shall continue to serve on a full-time basis as Employer&#146;s President and Chief Executive
Officer on the terms set forth in this Agreement, with the term of this Agreement to commence on
the Effective Date.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;NOW, THEREFORE, upon the above premises, and in consideration of the mutual covenants and
agreements hereinafter contained, the parties hereto agree as follows.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.&nbsp;<U>Engagement</U>. Effective as of the Effective Date, Employer shall continue to employ
Employee, and Employee shall continue to serve, as Employer&#146;s President and Chief Executive
Officer. Employee understands that his duties as President and Chief Executive Officer may change
from time to time over the term of this Agreement in the discretion of Employer&#146;s Board of
Directors, but such duties shall in all events be consistent with the duties customarily assigned
to the Chief Executive Officer of a company such as Employer.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.&nbsp;<U>Duties</U>. Place of Employment. Employee shall perform all duties assigned to him by
the Employer&#146;s Board faithfully, diligently and to the best of his ability. Such duties include,
without limitation, the overseeing and implementation of the business plan adopted by the Board (as
may be revised from time to time by the Board). Employee shall perform the services contemplated
under this Agreement in accordance with the policies established by and under the direction of the
Board of Directors. Employee shall have such corporate power and authority as shall reasonably be
required to enable him to discharge his duties under this Agreement. Employee&#146;s services hereunder
shall be rendered at Employer&#146;s offices in Worcester, Massachusetts (or such other location that is
then the corporate headquarters of Employer), except for travel when and as required in the
performance of Employee&#146;s duties hereunder.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.&nbsp;<U>Time and Efforts</U>. Employee shall devote all of his business time, efforts,
attention and energies to Employer&#146;s business and the discharge of his duties hereunder, except as
noted on Schedule&nbsp;A, which contains other potential activities of the Employee and disclosed
conflicts of interest.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.&nbsp;<U>Term</U>. The term (the &#147;Term&#148;) of Employee&#146;s employment shall commence on the
Effective Date and shall expire on December&nbsp;31, 2009, unless sooner terminated in accordance with
Section&nbsp;6. Neither Employer nor Employee shall have any obligation to extend or renew this
Agreement. In the event the Agreement shall not be extended or renewed by Employer beyond the
Term, Employer shall continue to pay Employee his salary as provided for in Section&nbsp;5.1 during the
period commencing on the date on which the Term ends and ending on the earlier of (a)&nbsp;June&nbsp;30, 2010
or (b)&nbsp;the date of Employee&#146;s re-employment with another employer (other than IPIFINI).
</DIV>

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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.&nbsp;<U>Compensation</U>. As the total consideration for Employee&#146;s services rendered under the
Agreement, Employer shall pay or provide Employee the following compensation and benefits:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.1 <U>Salary</U>. Commencing on the Effective Date, Employee shall be entitled to receive
an annual Base Salary of Three Hundred and Seventy Five Thousand ($375,000).
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.2 <U>Discretionary Bonus</U>. Employee may be eligible for an annual bonus for his
services during the Term. Employee&#146;s eligibility to receive a bonus, any determination to award
Employee such a bonus and, if awarded, the amount thereof shall be in Employer&#146;s sole discretion.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.3 <U>Stock Options</U>. The terms of the stock options granted to Employee under
Employer&#146;s 2007 Incentive Plan (the &#147;Stock Options&#148;) prior to the Effective Date, shall be governed
by Employee&#146;s employment agreement with the Employer dated as of February&nbsp;22, 2008. Employee shall
be eligible to receive additional grants of Stock Options during the term of this Agreement, as
shall be determined by Employer&#146;s Board of Directors in its sole discretion. In the event that the
Employee is terminated without Cause or resigns for Good Reason, with respect to any stock options
granted during the Term of this Agreement, the shares that would have vested during the Severance
Period (as defined in Section&nbsp;6.2 below) shall vest and become exercisable as of the date of such
termination.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.4 <U>Expense Reimbursement</U>. Employer shall reimburse Employee for reasonable and
necessary business expenses incurred by Employee in connection with the performance of Employee&#146;s
duties in accordance with Employer&#146;s usual practices and policies in effect from time to time.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.5 <U>Vacation</U>. Employee will be entitled to 25&nbsp;days of paid &#147;time off&#148; (vacation days
plus sick time/personal time) for each full calendar year in accordance with the Company&#146;s policies
from time to time in effect, in addition to holidays observed by the Company (for partial calendar
years, the Employee&#146;s paid &#147;time off&#148; will be pro-rated). Paid time off may be taken at such times
and intervals as the Employee shall determine, subject to the business needs of the Company, and
otherwise shall be subject to the policies of the Company, as in effect from time to time. The
number of paid &#147;time off&#148; days will accrue per pay period and will stop accruing once 20&nbsp;days have
been reached.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.6 <U>Employee Benefits</U>. Employee shall be eligible to participate in any medical
insurance and other employee benefits made available by Employer to all of its employees under its
group plans and employment policies in effect during the Term. Employee acknowledges and agrees
that, any such plans or policies now or hereafter in effect may be modified or terminated by
Employer at any time in its discretion.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.7 <U>Payroll Taxes</U>. Employer shall have the right to deduct from the compensation and
benefits due to Employee hereunder any and all sums required for social security and withholding
taxes and for any other federal, state, or local tax or charge which maybe in effect or hereafter
enacted or required as a charge on the compensation or benefits of Employee.
</DIV>


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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.&nbsp;<U>Termination</U>. The Agreement may be terminated as set forth in this Section&nbsp;6.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.1 <U>Termination by Employer for Cause or Voluntary Resignation Without Good Reason</U>.
Employer may terminate Employee&#146;s employment hereunder for &#147;Cause&#148; upon notice to Employee and
Employee may voluntarily resign his employment hereunder upon notice to Employer. &#147;Cause&#148; for this
purpose shall mean any of the following:
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;Employee&#146;s breach of any material term of the Agreement; provided that the first occasion
of any particular breach shall not constitute such Cause unless Employee shall have previously
received written notice from Employer stating the nature of such breach and affording Employee at
least ten days to correct such breach;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;Employee&#146;s conviction of, or plea of guilty or nolo contendere to, any felony or other
crime of moral turpitude;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;Employee&#146;s act of fraud or dishonesty injurious to Employer or its reputation;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;Employee&#146;s continual failure or refusal to perform his material duties as required under
the Agreement after written notice from Employer stating the nature of such failure or refusal and
affording Employee at least ten days to correct the same;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;Employee&#146;s act or omission that, in the reasonable determination of Employer&#146;s Board of
Directors (or a Committee of the Board), indicates alcohol or drug abuse by Employee; or
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f)&nbsp;Employee&#146;s act or personal conduct that, in the judgment of Employer&#146;s Board of Directors
(or a Committee of the Board), gives rise to a material risk of liability of Employee or Employer
under federal or applicable state law for discrimination, or sexual or other forms of harassment,
or other similar liabilities to subordinate employees.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Upon termination of Employee&#146;s employment by Employer for Cause or by Employee due to a
voluntary resignation without Good Reason, all compensation and benefits to Employee hereunder
shall cease and Employee shall be entitled only to payment, not later than three days after the
date of termination, of any accrued but unpaid salary and unused paid &#147;time off&#148; as provided in
Sections&nbsp;5.1 and 5.5 as of the date of such termination and any unpaid bonus that may have been
previously awarded Employee as provided in Section&nbsp;5.2 prior to such date.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.2 <U>Termination by Employer without Cause or by Employee for Good Reason</U>. Employer
may also terminate Employee&#146;s employment without Cause upon notice to Employee. Employee may also
terminate Employee&#146;s employment for Good Reason upon notice to the Employer. Upon termination of
Employee&#146;s employment by Employer without Cause or by Employee for Good Reason, all compensation
and benefits to Employee hereunder shall cease and Employee shall be entitled to payment of:
</DIV>


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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.3</div>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;any accrued but unpaid salary and unused paid &#147;time off&#148; as of the date of such
termination as required by Massachusetts law and any unpaid bonus that may have been previously
awarded Employee as provided in Section&nbsp;5.2 prior to such date, which shall be due and payable upon
the effective date of such termination;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;an amount, which shall be due and payable within ten (10)&nbsp;days following the effective
date of such termination, equal to the salary that would otherwise be payable as provided in
Section&nbsp;5.1 for the period of time which is equal to the earlier of either (i)&nbsp;the twelve-month
anniversary of such termination date; or (ii)&nbsp;the remainder of the Term of the Agreement but in no
event less than six(6) months (either (i)&nbsp;or (ii)&nbsp;shall be referred to as the &#147;Severance Period&#148;)
and
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;continued participation, at Employer&#146;s cost and expense, during the Severance Period in
any Employer sponsored group benefit plans in which Employee was participating as of the date of
termination.
</DIV>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">For purposes of this Agreement, Good Reason shall mean any of the following: (i)&nbsp;a material
reduction in Employee&#146;s duties, position, or responsibilities in effect immediately prior to such
reduction; (ii)&nbsp;the Company reduces Employee&#146;s Base Salary or bonus opportunity by more than 5%
relative to his salary and bonus opportunity in effect immediately prior to such
reduction;(iii)&nbsp;there is a material reduction by the Company in the kind or level of benefits to
which Employee is entitled immediately prior to such reduction with the result that Employee&#146;s
overall benefits package is significantly reduced; (iv)&nbsp;without Employee&#146;s express written consent,
Employee&#146;s relocation to a facility or a location more than fifty (50)&nbsp;miles from his then current
location in Worcester, Massachusetts; or (v)&nbsp;CytRx Corporation votes its shares of capital stock of
Employer to elect individuals who are affiliates of CytRx Corporation to constitute a majority of
the Employer&#146;s Board of Directors.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.4 <U>Death or Disability</U>. Employee&#146;s employment will terminate automatically in the
event of Employee&#146;s death or upon notice from Employer in event of his permanent disability.
Employee&#146;s &#147;permanent disability&#148; shall have the meaning ascribed to such term in any policy of
disability insurance maintained by Employer (or Employee, as the case may be) with respect to
Employee, or if no such policy is then in effect, shall mean Employee&#146;s inability to fully perform
his duties hereunder for any period of at least 75 consecutive days or for a total of 90&nbsp;days,
whether or not consecutive. Upon termination of Employee&#146;s employment as aforesaid, all
compensation and benefits to Employee hereunder shall cease and Employer shall pay to the
Employee&#146;s heirs or personal representatives, not later than ten days after the date of
termination, any accrued but unpaid salary and unused paid &#147;time off&#148; as of the date of such
termination as required by Massachusetts law and any unpaid bonus that may have been previously
awarded Employee as provided in Section&nbsp;5.2 prior to such date.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.&nbsp;<U>Confidentiality</U>. While this Agreement is in effect and for a period of four years
thereafter, Employee shall hold and keep secret and confidential all &#147;trade secrets&#148; (within the
meaning of applicable law) and other confidential or proprietary
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">information of Employer and shall
use such information only in the course of performing Employee&#146;s duties under this Agreement;
provided, however, that with respect to trade secrets, Employee shall hold and keep secret and
confidential such trade secrets for so long as they remain trade secrets under
applicable law. Employee shall maintain in trust all such trade secret or other confidential
or proprietary information, as Employer&#146;s property, including, but not limited to, all documents
concerning Employer&#146;s business, including Employee&#146;s work papers, telephone directories, customer
information and notes, and any and all copies thereof in Employee&#146;s possession or under Employee&#146;s
control. Upon the expiration or earlier termination of Employee&#146;s employment with Employer, or
upon request by Employer, Employee shall deliver to Employer all such documents belonging to
Employer, including any and all copies in Employee&#146;s possession or under Employee&#146;s control.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.&nbsp;<U>Equitable Remedies. Injunctive Relief</U>. Employee hereby acknowledges and agrees
that monetary damages are inadequate to fully compensate Employer for the damages that would result
from a breach or threatened breach of Section&nbsp;7 of this Agreement and, accordingly, that Employer
shall be entitled to equitable remedies, including, without limitation, specific performance,
temporary restraining orders, and preliminary injunctions and permanent injunctions, to enforce
such Section without the necessity of proving actual damages in connection therewith. This
provision shall not, however, diminish Employer&#146;s right to claim and recover damages or enforce any
other of its legal or equitable rights or defenses.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9.&nbsp;<U>Indemnification. Insurance</U>. Employer and Employee acknowledge that, as the Chief
Executive Officer of Employer, Employee shall be a corporate officer of Employer and, as such,
Employee shall be entitled to indemnification to the full extent mandated by Employer to its
officers, directors and agents under the Employer&#146;s Certificate of Incorporation and Bylaws as in
effect as of the date of this Agreement. Subject to his insurability there under, Employer shall
maintain Employee as an additional insured under its current policy of directors and officers
liability insurance and shall use commercially reasonable efforts to continue to insure Employee
there under, or under any replacement policies in effect from time to time, during the Term.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.&nbsp;<U>Severable Provisions</U>. The provisions of this Agreement are severable and if any
one or more provisions is determined to be illegal or otherwise unenforceable, in whole or in part,
the remaining provisions, and any partially unenforceable provisions to the extent enforceable,
shall nevertheless be binding and enforceable.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11.&nbsp;<U>Successors and Assigns</U>. This Agreement shall inure to the benefit of and shall be
binding upon Employer, its successors and assigns and Employee and his heirs and representatives;
provided, however, that neither party may assign this Agreement without the prior written consent
of the other party.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;12.&nbsp;<U>Entire Agreement</U>. This Agreement including Schedule&nbsp;A contains the entire
agreement of the parties relating to the subject matter hereof, and the parties hereto have made no
agreements, representations or warranties relating to the subject
</DIV>

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<DIV style="font-family: 'Times New Roman',Times,serif">
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">matter of this Agreement that are
not set forth otherwise therein or herein. Except as expressly provided herein, this Agreement
supersedes any and all prior or contemporaneous agreements, written or oral, between Employee and
Employer relating to the subject matter hereof. Any such prior or contemporaneous agreements are
hereby terminated and of no further effect, and Employee, by the execution hereof, agrees that any
compensation provided for under any such agreements is specifically superseded and replaced by the
provisions of this Agreement for services rendered from and after the Effective Date.
Notwithstanding the foregoing, the Invention Assignment
and Confidentiality Agreement dated February&nbsp;22, 2007, between the Employee and Employer shall
remain in force.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.&nbsp;<U>Amendment</U>. No modification of this Agreement shall be valid unless made in
writing, approved by the Employer&#146;s Board of Directors (or a committee of the Board) and signed by
the parties hereto and unless such writing is made by an executive officer of Employer (other than
Employee). The parties hereto agree that in no event shall an oral modification of this Agreement
be enforceable or valid.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;14.&nbsp;<U>Governing Law</U>. This Agreement is and shall be governed and construed in
accordance with the laws of the Commonwealth of Massachusetts without giving effect to
Massachusetts&#146;s choice-of-law rules.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15.&nbsp;<U>Notice</U>. All notices and other communications under this Agreement shall be in
writing and mailed, telecopied (in case of notice to Employer only) or delivered by hand or by a
nationally recognized courier service guaranteeing overnight delivery to a party at the following
address (or to such other address as such party may have specified by notice given to the other
party pursuant to this provision):
</DIV>
<DIV align="left" style="font-size: 10pt; margin-left: 6%; margin-top: 6pt">If to Employer:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-left: 6%; margin-top: 6pt">Legal Counsel<BR>
RXi Pharmaceuticals Corporation<BR>
60 Prescott St.<BR>
Worcester, MA 01605
</DIV>

<DIV align="left" style="font-size: 10pt; margin-left: 6%; margin-top: 6pt">If to Employee:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-left: 6%; margin-top: 6pt">Mr. Tod Woolf<BR>
14 Babe Ruth Drive<BR>
Sudbury, MA 01776
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;16.&nbsp;<U>Survival</U>. Sections&nbsp;8 through 19 shall survive the expiration or termination of
this Agreement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;17.&nbsp;<U>Counterparts</U>. This Agreement may be executed in counterparts, each of which shall
be deemed to be an original and all of which together shall be deemed to be one and the same
agreement.
</DIV>

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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;18.&nbsp;<U>Attorney&#146;s Fees</U>. In any action or proceeding to construe or enforce any provision
of this Agreement the prevailing party shall be entitled to recover its or his reasonable
attorneys&#146; fees and other costs of suit in addition to any other recoveries.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;IN WITNESS WHEREOF, this Agreement is executed as of the day and year first above written.
</DIV>

<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
<TR>
    <TD width="48%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>
<TR>
    <TD valign="top" align="left">&nbsp;</TD>
    <TD colspan="3" align="left">&#147;EMPLOYER&#148;<BR>
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD valign="top">By:&nbsp;&nbsp;</TD>
    <TD colspan="2" align="left" style="border-bottom: 1px solid #000000">&nbsp;/s/&nbsp;&nbsp;&nbsp;Sanford&nbsp; J. Hillsberg&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left">Sanford&nbsp; J. Hillsberg&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left">Chairman of the Board of Directors&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
<TR>
    <TD valign="top" align="left">&nbsp;</TD>
    <TD colspan="3" align="left">&#147;EMPLOYEE&#148;<BR>
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD valign="top">By:&nbsp;&nbsp;</TD>

<TD colspan="2" align="left" style="border-bottom: 1px solid #000000">&nbsp;/s/&nbsp;&nbsp;&nbsp;Tod Woolf&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left">Tod Woolf&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD colspan="2" align="left">&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>

</TABLE>

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<TABLE width="100%" border="0" cellspacing="0" cellpadding="0" style="font-size: 10pt">
<TR>
    <TD width="48%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="35%">&nbsp;</TD>
    <TD width="15%">&nbsp;</TD>
</TR>

</TABLE>

<DIV align="center" style="font-size: 10pt; margin-top: 18pt"><U><B>SCHEDULE A</B></U>
</DIV>



<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Mr.&nbsp;Woolf is on the Scientific Advisory Board of ProNai, a company that uses DNA to inactivate
genes.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Mr.&nbsp;Woolf is the President of IPIFINI, Inc., a company through which the above-mentioned
biomedical work is performed. IPIFINI, Inc. also has developed and owns several inventions outside
of the biomedical fields. Mr.&nbsp;Woolf and his family and friends may receive personal financial
compensation for any licenses taken to Invitrogen IP for which Mr.&nbsp;Woolf is a named inventor and
Mr.&nbsp;Woolf (and his family and friends) will receive a cash payment if Invitrogen meets certain
sales goals through November&nbsp;4, 2008. These inventions are in the field of RNAi, so they will
present a known potential conflict which will have to be managed, by having the board vote on any
potentially conflicting agreements with Invitrogen in the field of RNAi.
</DIV>


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</DIV>




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