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Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified | 12 Months Ended | 108 Months Ended
--- | --- | ---
Dec. 31, 2011 | Dec. 31, 2010 | Dec. 31, 2011
Cash flows from operating activities: |  |  |
Net loss | $ (11,485) | $ (11,993) | $ (77,269)
Adjustment to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization expense | 163 | 172 | 664
Loss on disposal of equipment | 7 |  | 19
Non-cash rent expense |  |  | 29
Accretion and receipt of bond discount |  |  | 35
Non-cash share based compensation | 3,001 | 4,368 | 18,858
Loss on exchange of equity instruments | 900 |  | 900
Fair value of shares mandatorily redeemable for cash upon exercise of warrants |  | (785) | (785)
Fair value of common stock warrants issued in exchange for services | 108 | 718 | 2,402
Fair value of common stock issued in exchange for services | 73 |  | 354
Change in fair value of common stock warrants | (9,881) | (3,049) | (12,072)
Fair value of common stock issued in exchange for licensing rights |  |  | 3,954
Change in fair value of contingent consideration | (109) |  | (109)
Changes in operating assets and liabilities: |  |  |
Prepaid expenses and other assets | (99) | (30) | (249)
Accounts payable | 500 | 99 | 1,224
Due to former parent |  |  | (207)
Deferred revenue | 816 |  | 816
Accrued expenses and other current liabilities | 1,338 | 243 | 2,658
Net cash used in operating activities | (14,668) | (10,257) | (58,778)
Cash flows from investing activities: |  |  |
Change in restricted cash | (101) |  | (101)
Cash received in acquisition | 168 |  | 168
Purchase of short-term investments |  | (5,990) | (37,532)
Maturities of short-term investments |  | 5,990 | 37,497
Cash paid for purchase of equipment and furnishings | (53) | (106) | (739)
Disposal of equipment and furnishings |  |  | (1)
Cash refunded (paid) for lease deposit |  |  | (45)
Net cash provided by (used in) investing activities | 14 | (106) | (753)
Cash flows from financing activities: |  |  |
Net proceeds from issuance of common stock | 18,615 | 15,235 | 64,982
Cash paid for repurchase of common stock |  | (3,849) | (3,849)
Net proceeds from exercise of common stock options |  | 254 | 610
Net proceeds from exercise of common stock warrants | 150 |  | 150
Common stock issued in connection with ESPP | 15 |  | 15
Net proceeds from issuance of convertible notes payable | 500 |  | 500
Repayments of capital lease obligations | (84) | (70) | (210)
Cash advances from former parent company, net |  |  | 8,766
Net cash provided by financing activities | 19,196 | 11,570 | 70,964
Net increase in cash and cash equivalents | 4,542 | 1,207 | 11,433
Cash and cash equivalents at the beginning of period | 6,891 | 5,684 |
Cash and cash equivalents at end of period | 11,433 | 6,891 | 11,433
Supplemental disclosure of cash flow information: |  |  |
Cash received during the periods for interest | 2 |  | 726
Cash paid during the periods for interest | 6 |  | 13
Supplemental disclosure of non-cash investing and financing activities: |  |  |
Settlement of corporate formation expenses in exchange for common stock |  |  | 978
Fair value of warrants issued in connection with common stock recorded as cost of equity | 12,709 | 2,466 | 18,038
Issuance of common stock in exchange of outstanding warrants | 3,120 |  | 3,120
Fair value of shares mandatorily redeemable for cash upon exercise of warrants |  | 785 | 785
Allocation of management expenses |  |  | 551
Equipment and furnishings exchanged for common stock |  |  | 48
Equipment and furnishings acquired through capital lease | 80 | 53 | 277
Non-cash lease deposit |  |  | 50
Value of restricted stock units and common stock issued in lieu of cash bonuses | 427 | 207 | 634
Apthera Acquisition: |  |  |
Fair value of shares issued to acquire Apthera | 6,367 |  | 6,367
Fair value of contingent purchase price consideration in connection with Apthera acquisition | 6,460 |  | 6,460
Net assets acquired excluding cash of $168 | $ 12,827 |  | $ 12,827

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- Definition The cash outflow to reacquire common stock during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=6943989&loc=d3e3291-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 18 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 20 -Subparagraph a -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The cash inflow associated with the sale, maturity and collection of all investments such as debt, security and so forth during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 31 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=6943989&loc=d3e3179-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 15 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 16 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 115 -Paragraph 18 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. + Details
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