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Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
 12 Months Ended 108 Months Ended
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2011
Cash flows from operating activities:      
Net loss $ (11,485) $ (11,993) $ (77,269)
Adjustment to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization expense 163 172 664
Loss on disposal of equipment 7   19
Non-cash rent expense     29
Accretion and receipt of bond discount     35
Non-cash share based compensation 3,001 4,368 18,858
Loss on exchange of equity instruments 900   900
Fair value of shares mandatorily redeemable for cash upon exercise of warrants   (785) (785)
Fair value of common stock warrants issued in exchange for services 108 718 2,402
Fair value of common stock issued in exchange for services 73   354
Change in fair value of common stock warrants (9,881) (3,049) (12,072)
Fair value of common stock issued in exchange for licensing rights     3,954
Change in fair value of contingent consideration (109)   (109)
Changes in operating assets and liabilities:      
Prepaid expenses and other assets (99) (30) (249)
Accounts payable 500 99 1,224
Due to former parent     (207)
Deferred revenue 816   816
Accrued expenses and other current liabilities 1,338 243 2,658
Net cash used in operating activities (14,668) (10,257) (58,778)
Cash flows from investing activities:      
Change in restricted cash (101)   (101)
Cash received in acquisition 168   168
Purchase of short-term investments   (5,990) (37,532)
Maturities of short-term investments   5,990 37,497
Cash paid for purchase of equipment and furnishings (53) (106) (739)
Disposal of equipment and furnishings     (1)
Cash refunded (paid) for lease deposit     (45)
Net cash provided by (used in) investing activities 14 (106) (753)
Cash flows from financing activities:      
Net proceeds from issuance of common stock 18,615 15,235 64,982
Cash paid for repurchase of common stock   (3,849) (3,849)
Net proceeds from exercise of common stock options   254 610
Net proceeds from exercise of common stock warrants 150   150
Common stock issued in connection with ESPP 15   15
Net proceeds from issuance of convertible notes payable 500   500
Repayments of capital lease obligations (84) (70) (210)
Cash advances from former parent company, net     8,766
Net cash provided by financing activities 19,196 11,570 70,964
Net increase in cash and cash equivalents 4,542 1,207 11,433
Cash and cash equivalents at the beginning of period 6,891 5,684  
Cash and cash equivalents at end of period 11,433 6,891 11,433
Supplemental disclosure of cash flow information:      
Cash received during the periods for interest 2   726
Cash paid during the periods for interest 6   13
Supplemental disclosure of non-cash investing and financing activities:      
Settlement of corporate formation expenses in exchange for common stock     978
Fair value of warrants issued in connection with common stock recorded as cost of equity 12,709 2,466 18,038
Issuance of common stock in exchange of outstanding warrants 3,120   3,120
Fair value of shares mandatorily redeemable for cash upon exercise of warrants   785 785
Allocation of management expenses     551
Equipment and furnishings exchanged for common stock     48
Equipment and furnishings acquired through capital lease 80 53 277
Non-cash lease deposit     50
Value of restricted stock units and common stock issued in lieu of cash bonuses 427 207 634
Apthera Acquisition:      
Fair value of shares issued to acquire Apthera 6,367   6,367
Fair value of contingent purchase price consideration in connection with Apthera acquisition 6,460   6,460
Net assets acquired excluding cash of $168 $ 12,827   $ 12,827