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CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY (USD $) | Total | September 2013 Common Stock Offering [Member] | Long-term Debt Financing [Member] | Common Stock [Member] | Additional Paid-in Capital [Member] | Additional Paid-in Capital [Member] September 2013 Common Stock Offering [Member] | Additional Paid-in Capital [Member] Long-term Debt Financing [Member] | Accumulated Other Comprehensive Income [Member] | Accumulated Deficit [Member] | Treasury Stock [Member]
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning balance at Dec. 31, 2010 | $ 2,430,000 |  |  | $ 2,000 | $ 62,020,000 |  |  | $ 0 | $ (55,743,000) | $ (3,849,000)
Beginning balance, shares at Dec. 31, 2010 |  |  |  | 19,047,759 |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |
Issuance of common stock, shares |  |  |  | 18,650,000 |  |  |  |  |  |
Issuance of common stock | 18,615,000 |  |  | 2,000 | 18,613,000 |  |  |  |  |
Common stock warrants issued in connection with common stock offering | (12,709,000) |  |  |  | (12,709,000) |  |  |  |  |
Issuance of stock in lieu of cash bonus, shares |  |  |  | 147,040 |  |  |  |  |  |
Issuance of stock in lieu of cash bonus | 171,000 |  |  |  | 171,000 |  |  |  |  |
Issuance of resticted stock units, shares |  |  |  | 220,729 |  |  |  |  |  |
Issuance of restricted stock units | 256,000 |  |  |  | 256,000 |  |  |  |  |
Issuance of common stock in exchange for services, shares |  |  |  | 53,558 |  |  |  |  |  |
Issuance of common stock in exchange for services | 73,000 |  |  |  | 73,000 |  |  |  |  |
Issuance of common stock upon exercise of warrants, shares |  |  |  | 4,301,000 |  |  |  |  |  |
Issuance of common stock upon exercise of warrants | 3,270,000 |  |  |  | 3,270,000 |  |  |  |  |
Issuance of common stock in connection with employee stock purchase plan, shares |  |  |  | 18,824 |  |  |  |  |  |
Issuance of common stock in connection with employee stock purchase plan | 15,000 |  |  |  | 15,000 |  |  |  |  |
Issuance of common stock in settlement of contingent purchase price consideration |  |  |  |  |  |  |  |  |  |
Issuance of common stock in settlement of contingent purchase price consideration, shares |  |  |  | 4,974,090 |  |  |  |  |  |
Issuance of common stock related to acquisition | 6,367,000 |  |  | 1,000 | 6,366,000 |  |  |  |  |
Issuance of common stock subject to employee termination agreements, shares |  |  |  | 398,453 |  |  |  |  |  |
Issuance of common stock subject to employee termination agreements | 350,000 |  |  |  | 350,000 |  |  |  |  |
Stock based compensation for directors and employees | 2,774,000 |  |  |  | 2,774,000 |  |  |  |  |
Stock based compensation for services | (15,000) |  |  |  | (15,000) |  |  |  |  |
Net liabilities distributed in connection with the RXi spin-off | 0 |  |  |  |  |  |  |  |  |
Net loss | (11,485,000) |  |  |  |  |  |  |  | (11,485,000) |
Ending balance at Dec. 31, 2011 | 10,112,000 |  |  | 5,000 | 81,184,000 |  |  | 0 | (67,228,000) | (3,849,000)
Ending balance, shares at Dec. 31, 2011 |  |  |  | 47,811,453 |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |
Issuance of common stock, shares |  |  |  | 25,486,960 |  |  |  |  |  |
Issuance of common stock | 36,378,000 |  |  | 2,000 | 36,376,000 |  |  |  |  |
Common stock warrants issued in connection with common stock offering | (7,286,000) |  |  |  | (7,286,000) |  |  |  |  |
Issuance of common stock in exchange for services, shares |  |  |  | 288,285 |  |  |  |  |  |
Issuance of common stock in exchange for services | 364,000 |  |  |  | 364,000 |  |  |  |  |
Issuance of common stock upon exercise of warrants, shares |  |  |  | 8,433,003 |  |  |  |  |  |
Issuance of common stock upon exercise of warrants | 16,551,000 |  |  | 1,000 | 16,550,000 |  |  |  |  |
Repurchase Of Common Stock Warrant | (266,000) |  |  |  | (266,000) |  |  |  |  |
Issuance of common stock in connection with employee stock purchase plan, shares |  |  |  | 234,350 |  |  |  |  |  |
Issuance of common stock in connection with employee stock purchase plan | 93,000 |  |  |  | 93,000 |  |  |  |  |
Issuance of common stock in settlement of contingent purchase price consideration, shares |  |  |  | 1,315,849 |  |  |  |  |  |
Issuance of common stock in settlement of contingent purchase price consideration | 1,579,000 |  |  |  | 1,579,000 |  |  |  |  |
Stock based compensation for directors and employees | 794,000 |  |  |  | 794,000 |  |  |  |  |
Stock based compensation for services | 600,000 |  |  |  | 600,000 |  |  |  |  |
Net liabilities distributed in connection with the RXi spin-off | 2,159,000 |  |  |  | 2,159,000 |  |  |  |  |
Unrealized gain on marketable securities, net of tax | 1,626,000 |  |  |  |  |  |  | 1,626,000 |  |
Exercise of stock options, shares |  |  |  | 25,937 |  |  |  |  |  |
Exercise of stock options | 21,000 |  |  |  | 21,000 |  |  |  |  |
Net loss | (34,969,000) |  |  |  |  |  |  |  | (34,969,000) |
Ending balance at Dec. 31, 2012 | 27,756,000 |  |  | 8,000 | 132,168,000 |  |  | 1,626,000 | (102,197,000) | (3,849,000)
Ending balance, shares at Dec. 31, 2012 |  |  |  | 83,595,837 |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |
Issuance of common stock, shares |  |  |  | 20,125,000 |  |  |  |  |  |
Issuance of common stock | 37,539,000 |  |  | 2,000 | 37,537,000 |  |  |  |  |
Common stock warrants issued in connection with common stock offering |  | (8,238,000) | 351,000 |  |  | (8,238,000) | 351,000 |  |  |
Issuance of common stock upon exercise of warrants, shares |  |  |  | 5,320,669 |  |  |  |  |  |
Issuance of common stock upon exercise of warrants | 22,064,000 |  |  |  | 22,064,000 |  |  |  |  |
Issuance of common stock in connection with employee stock purchase plan, shares | 243,510 |  |  | 52,532 |  |  |  |  |  |
Issuance of common stock in connection with employee stock purchase plan | 163,000 |  |  |  | 163,000 |  |  |  |  |
Issuance of common stock in settlement of contingent purchase price consideration, shares |  |  |  | 492,988 |  |  |  |  |  |
Issuance of common stock in settlement of contingent purchase price consideration | 1,247,000 |  |  |  | 1,247,000 |  |  |  |  |
Issuance of common stock related to acquisition | 0 |  |  |  |  |  |  |  |  |
Issuance of common stock in exchange for services, shares |  |  |  | 99,998 |  |  |  |  |  |
Issuance of common stock in exchange for services | 211,000 |  |  |  | 211,000 |  |  |  |  |
Stock based compensation for directors and employees | 1,886,000 |  |  |  | 1,886,000 |  |  |  |  |
Stock based compensation for services | 644,000 |  |  |  | 644,000 |  |  |  |  |
Net liabilities distributed in connection with the RXi spin-off | 0 |  |  |  |  |  |  |  |  |
Reclassification of unrealized gain upon the sale of marketable securities, net of tax of $1,052 | (1,626,000) |  |  |  |  |  |  | (1,626,000) |  |
Exercise of stock options, shares | 289,000 |  |  | 413,677 |  |  |  |  |  |
Exercise of stock options | 567,000 |  |  |  | 567,000 |  |  |  |  |
Net loss | (76,678,000) |  |  |  |  |  |  |  | (76,678,000) |
Ending balance at Dec. 31, 2013 | $ 5,886,000 |  |  | $ 10,000 | $ 188,600,000 |  |  | $ 0 | $ (178,875,000) | $ (3,849,000)
Ending balance, shares at Dec. 31, 2013 |  |  |  | 110,100,701 |  |  |  |  |  |

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