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Warrants (Tables) | 12 Months Ended
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Dec. 31, 2013
Warrants and Rights Note Disclosure [Abstract] |
Schedule of Warrant Activity | The following is a summary of warrant activity for the years ended December 31, 2013 and 2012 (in thousands):
| September 2013 Warrants |  | December 2012 Warrants |  | April 2011 Warrants |  | March 2011 Warrants |  | March 2010 Warrants |  | August 2009 Warrants |  | Consultant and Oxford Warrants |  | Total
Outstanding, January 1, 2012 | — |  |  | — |  |  | 9,470 |  |  | 2,400 |  |  | 540 |  |  | 978 |  |  | 733 |  |  | 14,121 |
Granted | — |  |  | 7,578 |  |  | — |  |  | — |  |  | — |  |  | — |  |  | 400 |  |  | 7,978 |
Exercised | — |  |  | — |  |  | (6,624 | ) |  | (2,039 | ) |  | (180 | ) |  | — |  |  | (40 | ) |  | (8,883 | )
Outstanding, December 31, 2012 | — |  |  | 7,578 |  |  | 2,846 |  |  | 361 |  |  | 360 |  |  | 978 |  |  | 1,093 |  |  | 13,216 |
Granted | 7,044 |  |  | — |  |  | — |  |  | — |  |  | — |  |  | — |  |  | 182 |  |  | 7,226 |
Exercised | (602 | ) |  | (2,661 | ) |  | (1,688 | ) |  | (185 | ) |  | (70 | ) |  | — |  |  | (196 | ) |  | (5,402 | )
Expired | — |  |  | — |  |  | — |  |  | — |  |  | — |  |  | — |  |  | (190 | ) |  | (190 | )
Outstanding, December 31, 2013 | 6,442 |  |  | 4,917 |  |  | 1,158 |  |  | 176 |  |  | 290 |  |  | 978 |  |  | 889 |  |  | 14,850 |
Expiration | September 2018 |  | December 2017 |  | April 2017 |  | March 2016 |  | March 2016 |  | August 2014 |  | Varies 2014-2020 |  |
Fair Value of Warrants is Estimated Using Black-Scholes Option Pricing Model | The fair value of the warrants is estimated using an appropriate pricing model with the following inputs:
| As of December 31, 2013
| September 2013 Warrants |  | December 2012 Warrants |  | April 2011 Warrants |  | March 2011 Warrants |  | March 2010 Warrants |  | August 2009 Warrants
Strike price | $ | 2.50 |  |  | $ | 1.90 |  |  | $ | 0.65 |  |  | $ | 0.65 |  |  | $ | 2.15 |  |  | $ | 4.50 |
Expected term (years) | 4.72 |  |  | 3.98 |  |  | 3.31 |  |  | 2.18 |  |  | 2.24 |  |  | 0.59 |
Volatility % | 71.97 | % |  | 71.38 | % |  | 71.71 | % |  | 73.45 | % |  | 73.36 | % |  | 66.85 | %
Risk-free rate % | 1.61 | % |  | 1.25 | % |  | 0.93 | % |  | 0.45 | % |  | 0.47 | % |  | 0.11 | %
| As of December 31, 2012
| September 2013 Warrants |  | December 2012 Warrants |  | April 2011 Warrants |  | March 2011 Warrants |  | March 2010 Warrants |  | August 2009 Warrants
Strike price | — |  |  | $ | 1.90 |  |  | $ | 0.65 |  |  | $ | 0.65 |  |  | $ | 2.18 |  |  | $ | 4.50 |
Expected term (years) | 0.00 |  |  | 4.98 |  |  | 4.30 |  |  | 3.18 |  |  | 3.24 |  |  | 1.59 |
Volatility % | — |  |  | 80.93 | % |  | 82.48 | % |  | 69.90 | % |  | 69.79 | % |  | 74.13 | %
Risk-free rate % | — |  |  | 0.72 | % |  | 0.59 | % |  | 0.39 | % |  | 0.40 | % |  | 0.21 | %
Changes in Fair Value of Warrant Liability | The changes in fair value of the warrant liability for the years ended December 31, 2013 and 2012 were as follows (in thousands):
| September 2013 Warrants |  | December 2012 Warrants |  | April 2011 Warrants |  | March 2011 Warrants |  | March 2010 Warrants |  | August 2009 Warrants |  | Total
Warrant liability, January 1, 2012 | $ | — |  |  | $ | — |  |  | $ | 3,145 |  |  | $ | 421 |  |  | $ | 116 |  |  | $ | 64 |  |  | $ | 3,746 |
Fair value of warrants granted | — |  |  | 7,286 |  |  | — |  |  | — |  |  | — |  |  | — |  |  | 7,286 |
Fair value of warrants exercised | — |  |  | — |  |  | (8,130 | ) |  | (2,456 | ) |  | (257 | ) |  | — |  |  | (10,843 | )
Change in fair value of warrants | — |  |  | (332 | ) |  | 8,295 |  |  | 2,413 |  |  | 328 |  |  | 71 |  |  | 10,775 |
Warrant liability, December 31, 2012 | — |  |  | 6,954 |  |  | 3,310 |  |  | 378 |  |  | 187 |  |  | 135 |  |  | 10,964 |
Fair value of warrants granted | 8,238 |  |  | — |  |  | — |  |  | — |  |  | — |  |  | — |  |  | 8,238 |
Fair value of warrants exercised | (1,931 | ) |  | (8,482 | ) |  | (3,455 | ) |  | (260 | ) |  | (121 | ) |  | — |  |  | (14,249 | )
Change in fair value of warrants | 16,643 |  |  | 19,588 |  |  | 5,214 |  |  | 645 |  |  | 879 |  |  | 1,043 |  |  | 44,012 |
Warrant liability, December 31, 2013 | $ | 22,950 |  |  | $ | 18,060 |  |  | $ | 5,069 |  |  | $ | 763 |  |  | $ | 945 |  |  | $ | 1,178 |  |  | $ | 48,965 |

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