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CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $) In Thousands, unless otherwise specified | 9 Months Ended | 12 Months Ended
--- | --- | ---
Sep. 30, 2012 | Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011
Cash flows from operating activities: |  |  |  |
Net loss |  | $ (76,678) | $ (34,969) | $ (11,485)
Adjustment to reconcile net loss to net cash used in operating activities: |  |  |  |
Depreciation and amortization expense |  | 452 | 49 | 163
Loss on disposal of equipment |  | 0 | 0 | 7
Gain on sale of marketable securities |  | (3,911) | 0 | 0
Deferred taxes |  | 1,052 | (1,052) |
Non-cash stock-based compensation |  | 2,530 | 1,394 | 3,001
Fair value of common stock warrants issued in exchange for services |  |  | 0 | 108
Fair value of common stock issued in exchange for services |  | 211 | 364 | 73
Change in fair value of common stock warrants |  | 44,001 | 10,775 | (8,981)
Change in fair value of contingent consideration |  | 926 | 2,370 | (109)
Changes in operating assets and liabilities: |  |  |  |
Accounts receivable |  | (3,683) | 0 | 0
Inventories |  | (386) | 0 | 0
Prepaid expenses and other assets |  | (832) | (396) | (99)
Accounts payable |  | 684 | 641 | 500
Accrued expenses and other current liabilities |  | 6,726 | (139) | 2,154
Net cash used in operating activities |  | (28,908) | (20,963) | (14,668)
Cash flows from investing activities: |  |  |  |
Change in restricted cash |  | (99) |  | (101)
Cash paid for acquisition of Abstral rights |  | (15,143) |  |
Cash received in Apthera acquisition |  | 0 | 0 | 168
Proceeds from sale of marketable securities |  | 3,911 | 0 | 0
Cash paid for purchase of equipment and furnishings |  | (705) |  | (53)
Cash transferred with the RXi spin-off |  |  | (87) |
Net cash provided by (used in) investing activities |  | (12,036) | (87) | 14
Cash flows from financing activities: |  |  |  |
Net proceeds from issuance of common stock |  | 37,539 | 36,378 | 18,615
Cash paid for repurchase of warrants |  |  | (266) |
Net proceeds from exercise of stock options |  | 567 | 21 |
Proceeds from exercise of warrants |  | 7,815 | 5,708 | 150
Proceeds from common stock issued in connection with ESPP |  | 163 | 93 | 15
Net proceeds from issuance of RXi convertible notes payable |  |  | 500 | 500
Net proceeds from issuance of long-term debt |  | 9,865 | 0 | 0
Repayments of capital lease obligations |  | (25) | (10) | (84)
Net cash provided by financing activities |  | 55,924 | 42,424 | 19,196
Net increase in cash and cash equivalents |  | 14,980 | 21,374 | 4,542
Cash and cash equivalents at the beginning of period | 11,433 | 32,807 | 11,433 | 6,891
Cash and cash equivalents at end of period |  | 47,787 | 32,807 | 11,433
Supplemental disclosure of cash flow information: |  |  |  |
Cash received during the periods for interest | 1 | 19 |  | 2
Cash paid during the periods for interest | 1 | 547 |  | 6
Supplemental disclosure of non-cash investing and financing activities: |  |  |  |
Fair value of warrants issued in connection with common stock recorded as cost of equity | 7,286 | 8,238 |  | 12,709
Issuance of common stock in exchange of outstanding warrants | 0 | 0 |  | 3,120
Net liabilities distributed in connection with the RXi spin-off | 2,246 | 0 | 2,159 | 0
Reclassification of warrant liabilities upon exercise | 10,843 | 14,249 | (10,843) |
Issuance of common stock in settlement of contingent purchase price consideration | 1,579 | 1,247 | 1,579 |
Change in fair value of marketable securities before settlement | 2,678 | (2,678) |  |
Fair value of shares issued to acquire NeuVax | 0 | 0 |  | 6,367
Fair value of contingent purchase price consideration in connection with NeuVax acquisition | 0 | 0 |  | 6,460
Net assets acquired, excluding cash of $168 |  | $ 0 | $ 0 | $ 12,827

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